in my opinion, quality of life is better down south, depending on your standards.
I moved from Manchester 10 years ago, I've lived all over London, I've stayed in cramped places and spacious places from zone 1-3.
When we decided to buy a property, we were actually looking to move back, but I decided against it for many reasons why I chose to leave!
We could only afford really a 210k two double two bathroom apartment in zone 5. (A borough that a lot of mumsnetters sneer at lol) but we only have one daughter, and we are not having anymore. She has her own bathroom and large double room. We have a balcony, large lounge and big kitchen. Underground parking and communal gardens. Gated.
Okay I haven't got a garden but I have 3 "country"Parks next to my complex. and 15 mins drive away, I have Richmond Park. 25 min - 30 drive, I've got Westfields, and central London. 25 mins the other way, I have the likes of Windsor, Thorpe Park, And many other beautiful location, 15 mins east I have Hampton Palace and such locations. Brighton is what? 1 1/2 hour away. wheeze my friend even drives to Southampton for uni most days, and makes it back in time for dinner.
If I don't send DD to private school, majority of the schools are rated Outstanding.
I'd rather have this than the 20 min drive to Manchester town and be claustrophobic, or a 15 min drive to Trafford centre lol.
So I think my quality of life is way better than I could ever imagine if I'm honest. I think a lot of northerners (including my family and friends back home) seem to think we all live in a studio flat cramped all our lives. I do live in a area where it's good to have a car, but even if I didn't we have buses running all the time, the tube, and Heathrow not far away.
Obvs it would only be sensible to live in central London if you COULD AFFORD the properties.