I haven't read the original thread, so getting this at secondhand. Howver, I have read and listened to a lot of David Sedaris, and seen him live. 'Whore' is something he calls his long-time, much-loved and very handsome husband in a sketch/essay where he describes goading his husband (Hugh) into listing his previous sexual encounters. The word is used once, right at the end of the sketch (to the audience, not 'to' Hugh), and provokes a laugh because it exposes the absurdity of the jealousy and angry judgement of his partner that he - Sedaris - has brought down on his own head. It's making the audience complicit with Sedaris' exposure of his own idiocy. So far as I know, it's the only time he uses the word whore in his repertoire. Maybe he did that sketch on the night of the signing, to great applause, and it was an in-joke with members of the audience?
He is, in one sense, a really old-fashioned - I mean, like 17th/18th century - humourist. His work is constructed around the paradoxes and weirdness of what his own sensibility makes of the world around him, and how impervious the self is to censorship and moral disapproval. So he visits the Anne Frank museum and wants to think about survival and intolerance, but finds himself wishing he owned the house and how he would renovate it. The reading I attended, he took questions from the audience and one person asked, 'What do you like about living in the UK?' - plainly an attempt to build bridges and give him a chance to leave the audience iwth a fuzzy glow. He answered, "In your supermarkets, you have really good ice-cream. You don't get that in the States."
I like him, but yeah, he's a strange one. Anyway, OP, thank you for making me think about David Sedaris - more interesting than cleaning the limescale off the shower!