I've done this loads of times without packers.
Start early and de clutter as much as possible. Be ruthless about getting rid of things you don't need - you'll soon forget about them. Start taking stuff to the charity shop/tip ASAP.
Don't pack too much heavy stuff in each box - just one or two heavy items and then lighter items, or you risk the boxes breaking.
Mark boxes according to the (main) room they correspond to. In my last move, I numbered the boxes and had a spreadsheet with roughly what was in them so when it came to unpacking I knew what to prioritise. Bit geeky but helpful!
Use original boxes for any appliances where you have them - especially useful for TVs and more delicate items. Where you don't have them, try wrapping items in blankets or bubble wrap. You'll want to keep these boxes in future!
Have several pairs of scissors and rolls of tape around the house!
Wrap delicate items in clothes and scarves - save bubble wrap for where it's really needed.
Despite all this, you'll find yourself shoving loads of random stuff in boxes at the last minute! Never underestimate how many boxes and bags you'll need for those last minute items so keep any bags free and unpacked so you can fill them up at the last minute. This includes tote bags, suitcases, travel bags etc. They will all come in handy!
Good luck OP! It's stressful but hopefully it'll be worth it 
The unpacking is probably worse actually...!