I'm sure there are other people in the same boat and wondered what people do.
I took a break from my career in 2009 after dd2 was born. Since then there has been a recruitment freeze so no chance of returning. In 2010 I did some agency work in a related field but agency work also dried up so I got a permanent job in a different area. I've been in that job ever since.
There are some aspects of my current job that are related to my original career but the longer I am out, the more remote I feel it is that I'll be able to return because my knowledge and skills will be out of date. I am worried I've thrown my career down the drain.