Difference isn't a threat. Ignorance is.
But difference can be a threat. I'm a middle aged woman. Well late middle aged, truth be told. I like running. I like running in the countryside, where there aren't many people. I see someone coming towards me on the path ahead.
it's a large man in his early 30s
its a small woman my age
its a teenage girl
its a teenage boy
in this situation I would be mad not to take into account the difference between myself and the other person when considering the risk they might pose to me
ignorance, yes, can be a threat
ignorance of the importance of handwashing
ignorance of the dangers of smoking
ignorance of how to manage a personal budget
etc etc
ignorance of the meaning of various 'gender identities' which didn't exist before last week, no, that's not a threat