I reckon it will take quite a lot longer than 100 years of evolution for the binary nature of all mammals , the large and small gametes associated with female and male mammals that determine how sexual reproduction in mammals occurs, the skeletal difference in male and female human bodies, and the clearly identifiable chromosomal structure of the human genome that shows how our dna is inherited from our male and female parents to change our understanding of what makes a person either male or female.
But hey, who knows, maybe the suggestion that there are male and female brains - and of course assuming the male/ female brain thing overrides all the physiological stuff, and then trumps all that well documented evolutionary science - means we can happily abandon pronouns forever.
But let’s start with the easy stuff.
Sex in mammals is binary. Sex is fixed ,you can’t change it.
Gender is a social concept, gender is not sex, gender is not interchangeable with sex.