I came across an interesting thread on TwiX discussing this trial and thought it was relevant to this thread:
https://threadreaderapp.com/thread/1944280856752795768.html
The puberty blocker "trial" isn't as a real clinical trial, but rather a way for the medical profession to wash their hands of the children currently taking puberty blockers.
There arguably can be "no limit" so that the NHS can shift as many children currently taking puberty blockers onto the "trial".
These children are clinical negligence claimants, as they have been prescribed puberty blockers with what the Cass Review said was unclear rationale and weak evidence.
However if they are entered onto the trial, they can become "unfortunate clinical trial outcomes" and the medical profession can wash their hands of them.