As @Plasmodesmata and @50mg have said, the issue for me isn't so much her perspective on trans issues. I disagree with her, but I can live with that. It's her integrity. Boris will happily claim that up is down if he thinks it'll win him support. We don't need a repeat.
It's also her judgement. That campaign video, and the people it featured, demostrated monumentally poor judgement.
And the opinion of Frost really is the death knell for me. Incompetent, not in charge of her brief, and dishonest. Better the bushy haired shagger we know.
It's sort of academic, as I don't have a vote. But I really hope she doesn't win, for many more reasons than that she thinks TWAW.