By the way, how many regulars have seen this study?
Baker, K. E., et al, (2021) Hormone Therapy, Mental Health and Quality of Life Among Transgender People: A Systematic Review. Journal of the Endocrine Society.
academic.oup.com/jes/article/5/4/bvab011/6126016
It has some very interesting conclusions to draw about the studies that focus on adolescents. I posted it on another thread, but to make it easy for everyone to find.
Quality of Life
Among adolescents, a mixed-gender prospective cohort (n = 50) showed no difference in QOL scores after a year of endocrine interventions, which included combinations of GnRH analogues and estrogen or testosterone formulations [30]. No study found that hormone therapy decreased QOL scores. We conclude that hormone therapy may improve QOL among transgender people. The strength of evidence for this conclusion is low due to concerns about bias in study designs, imprecision in measurement because of small sample sizes, and confounding by factors such as gender-affirming surgery status.
And this under Depression
Among adolescents, 2 mixed-gender prospective cohorts (n = 50 and n = 23, respectively) showed improvements in depression scores after 1 year of treatment with GnRH analogues and estrogen or testosterone formulations (both P < 0.001) [30, 38]. Another prospective study reported that BDI scores improved almost by half among adolescents (n = 41) after a mean of 1.88 years of treatment with GnRH analogues to delay puberty (P = 0.004) [34]. The overall improvement after several subsequent years of testosterone or estrogen therapy in this cohort (n = 32) was smaller, however, resulting in no significant change from baseline [35]. No study found that hormone therapy increased depression.
Anxiety
Among adolescents, 1 prospective study saw mean anxiety scores in a mixed-gender group (n = 23) improve from 33.0 ± 7.2 to 18.5 ± 8.4 after 1 year (P < 0.001) [38], but another reported no changes in anxiety after approximately 2 years of puberty delay treatment with GnRH analogues and 4 years of hormone therapy (n = 32) [35].
Suicide
The risk of bias for this study was serious due to the difficulty of identifying appropriate comparison groups and uncontrolled confounding by surgery status and socioeconomic variables such as unemployment. We cannot draw any conclusions on the basis of this single study about whether hormone therapy affects death by suicide among transgender people.
If anyone has seen it before, I'd love to know where you saw it mentioned.
For those who will not read these paragraphs or look at the original source from which they are copied...
It seems there is no conclusive evidence among 20 studies (albeit the studies were all age groups so not that many focused on adolescents) that adolescents who are given hormone therapy (puberty blockers or testosterone) had improved long term mental health across the four areas reviewed. One may be showed a positive effect in depression but it was not supported in another study which was of longer term.
Happy to see another viewpoint of the study.
Remember though, it is evidence some of us would like to see, for those positive effects of puberty blockers and CSH on adolescent girls and children - short term and long term that we are being told are well supported with over decades of evidence.