From various articles available on Lupron which as I understand it, is typical of the class of drugs commonly used as puberty blockers. I know there are a few different types but presumably as they are broadly similar in their function, they may have broadly similar issues?
This first article sounds rather concerning. An IQ drop of 8 points is initially dismissed as not significant but in the same way as the lack of increase in bone density at an absolutely key stage of development (where it should be increasing enormously), any drop in IQ at this stage of a child's life and development should be huge cause for concern. Reports from individual patients show a more serious situation for some children.
A study of GnRHa’s in 2001 showed “IQ levels decreased significantly” (a mean 7 point drop, but “doubts exist about the clinical relevance”), and in 2016 another GnRHa study reported an IQ drop of around 8 points was noted (which was found in the study to be “not significant”). These studies were conducted outside the US, but within the US Lupron dominates the market. Where are the pediatric (or adult) Lupron IQ studies, and why do these pediatric studies dismiss the significant decreases in IQ? Wouldn’t any IQ drop of 8 points be significant? This is information that would be critical to the decision-making of any parent/child. And the “doubts” about clinical relevance and ‘non-significance’ of GnRHa-induced intelligence decline should be pursued by the media – and medicine.
One mother who contacted me reported after the first Lupron injection her child experienced:
“Complete inability to focus on anything – grades plummeted … couldn’t remember where either tooth paste or brush were located, or sock drawer. Could not repeat simple instructions or follow them. Our sunshine child was sad and without typical ‘I can do anything’ attitude.”
“My own story is that after taking Lupron [for endometriosis] I now have bone loss, severe bone and joint pain requiring heavy painkillers to get out of bed, chest pain, tachycardia, fibromyalgia and horrible memory loss, hair loss and weight gain. Prior to Lupron I ran and boxed everyday. I was healthy even though endometriosis caused significant pain. It has now been a year since my Lupron treatments and my life is in medical shambles.”
The FDA reports that, as long ago as 1999, it had received adverse drug reports about Lupron® from 4,228 women and 2,943 men.1 These side effects included: tingling, itching, headache and migraine, dizziness, severe joint pain, difficulty breathing, chest pain, nausea, depression, emotional instability, dimness of vision, fainting, weakness, amnesia, hypertension, muscular pain, bone pain, nausea/vomiting, asthma, abdominal pain, insomnia, chronic enlargement of the thyroid, liver function abnormality, vision abnormality, and anxiety, and others.2 In 325 of these cases, the women required hospitalization; 25 women died.3 At the time, the FDA said that it did not have enough staff capacity to assess any causal effect in these cases.
As with many drugs, side effects have long been a problem. More than 20,000 adverse-event reports have been filed with the FDA in the last decade. Women have reported to the FDA hundreds of cases of insomnia, depression, joint pain, and more than 100 cases of blurred vision. About 900 reports cite side effects that children below age 13 have suffered, mostly within months of taking Lupron. Those reports frequently note injection-site pain but also include dozens of cases of bone problems, such as pain or disorders, and the inability to walk.
www.hormonesmatter.com/lupron-precocious-puberty-decades-regulatory-silence/
www.statnews.com/2017/02/02/lupron-puberty-children-health-problems/
nwhn.org/lupron-what-does-it-do-to-womens-health/