I can only talk from my experiance, I'm lucky in the sense that most people I know don't agree with modern day trans ideology. I have even been surprised at specific people who have agreed with me as they tend to pass themselves off as 'super woke' on the surface but it seems to be a form of self preservation in today's hostile political climate but even they can see the issues that come with TRA ideplogy especially when it concerns children.
I do have one friend who frustrates me because whn we discuss this issue, she doesnt seem to get what I'm telling her. I always make it clear that Im not against Trans individuals but am opposed at the modern day Transgender movements ridiculous demands and denial of biology, but she always seems to bring it back to a couple of transgender colleges she has and how "They've never acted like that" or"Ive never seen that". It frustrates me because I know, going by our convo's over the years on this topic, she never does any further research into this issue beyond her own personal interaction with these particular colleges.
The most frustrating thing about this? She works in the psychology field and the core aspect of her job is research.
However our while our conversation on this topic can get heated, our friendship hasnt suffered because, as well as having a multitude of other topis we enjoy talking about, we can comfortably agree to disagree. Funnily enough another friend in the same friend group got really upset with me after a few times talking about this subject and kind of went off at me on our group chat but now agrees with me after seeing certain articles on how TRA's and Stonewall treat lesbians.
I adore my friend group but if any of them went down the rabbit whole of black and white thinking, or started to get all super woke on me about this issue to the ideological point of how mosy TRA's ad their 'allies' act, then I would put some distance between myself and them, maybe temporarily or if need be permanently.
I don't listen to nutty street preachers who tell me I'm a 'heathen' or that I'm going to hell for not following their religion or God, Im not going to listen to gender activists who shout out TERF at any opposition to their world view either. All of these fundamentalist people can get in the bin as far as Im concerned.
OP while you may value your friend you have to see if they value you in the same way or if they've gone down a different track. Someone that makes you feel anxious and nervous at expresing opposing views to them and joins in on a pile on of you in social media conversations may not have the same idea about the friendship that you have. I'm not saying cut them off straight away, but observe their behavior and see if you are being valued the same way you value them.
Good luck! 