Oh gosh, nightmare, now the links didn't work, and preview isn't working so I couldn't check. I wish we had an edit button.
(you can delete my other postS, I edited it myself to make it bold 😊 sorry for the double posting)
"Still two games apparently. The six "sexes" are(copied from the article):
X – Roughly 1 in 2,000 to 1 in 5,000 people (Turner’s ) - female
XX – Most common form of female
XXY – Roughly 1 in 500 to 1 in 1,000 people (Klinefelter) - male
XY – Most common form of male
XYY – Roughly 1 out of 1,000 people - male
XXXY – Roughly 1 in 18,000 to 1 in 50,000 births" - male
Nah. There are two sexes.
I don't think these are classed as intersex either. Unless I'm mistaken. From what I'm reading about them they don't have "intersex" effects in terms of intersex genitalia and/or sex organs, and/or mismatch between sex chromosomes and phenotype, (unlike the XY androgen insensitivity/complete androgen insensitivity syndrome, and issues with the SRY gene, also mentioned in this thread). The different sex chromosome combinations on Joshua's list are conditions, genetic disorders affecting either males or females.
Others on the list have been linked to on the list, this is the last one on the list
XXXY
en.m.wikipedia.org/wiki/XXXY_syndrome
"XXXY syndrome is a genetic disorder characterized by a sex chromosome aneuploidy, where males have two extra X chromosomes.[1] Males typically have only two sex chromosomes, an X and a Y. The presence of one Y chromosome with a functioning SRY gene causes the expression of genes that determine maleness. Because of this, XXXY syndrome only affects males. The additional two X chromosomes in males with XXXY syndrome causes them to have 48 chromosomes, instead of the typical 46. So, XXXY syndrome is often referred to as 48, XXXY. There are a wide variety of symptoms associated with this syndrome, including cognitive and behavioral problems, Taurodontism, and infertility.[1][2] This syndrome is usually inherited via a new mutation in one of the parents’ gametes, as those affected by it are usually infertile. It is estimated that XXXY affects one in every 50,000 male births"
Others that are NOT on Joshua's list, showing that he didn't bother even googling what he decided to talk about without knowing his facts and instead just repeating some bs:
XXX
en.m.wikipedia.org/wiki/Triple_X_syndrome
"Triple X syndrome, also known as trisomy X and 47,XXX, is characterized by the presence of an extra X chromosome in each cell of a female.[1] Those affected are often taller than average.[1] Usually there are no other physical differences and normal fertility.[1] Occasionally there are learning difficulties, decreased muscle tone, seizures, or kidney problems.[1]
Triple X is due to a random event.[1] Triple X can result either during the division of the mother's reproductive cells or during division of cells during early development.[2] It is not typically inherited from one generation to the next.[1] A form where only a percentage of the body cells contain XXX can also occur.[1] Diagnosis is by chromosomal analysis.[3]
Treatment may include speech therapy, physical therapy, and counseling.[3] It occurs in about one in every 1,000 female births.[2] It is estimated that 90% of those affected are not diagnosed as they either have no or only few symptoms.[2] It was first identified in 1959.[4]"
XXXX
en.m.wikipedia.org/wiki/Tetrasomy_X
"This condition occurs only in females, as there are no Y chromosomes present.
Tetrasomy X was first described in 1961, and since then approximately 100 cases have been reported worldwide. Approximately 60 affected females have been described in the medical literature"
XXXXY
en.m.wikipedia.org/wiki/49,XXXXY
"49,XXXXY syndrome is an extremely rare aneuploidic sex chromosomal abnormality. It occurs in approximately 1 out of 85,000 to 100,000 males.
Aneuploidy is often fatal, but in this case there is "X-inactivation" where the effect of the additional gene dosage due to the presence of extra X chromosomes is greatly reduced.[3]
Much like Down syndrome, the mental effects of 49,XXXXY syndrome vary. Impaired speech and behavioral problems are typical.[4] Those with 49,XXXXY syndrome tend to exhibit infantile secondary sex characteristics with sterility in adulthood and have some skeletal anomalies. Skeletal anomalies include..."
XXXXX
en.m.wikipedia.org/wiki/Pentasomy_X
"The condition is extremely rare, with less than forty reported cases as of 2011." Oh look another rare sex sarcasm
"Pentasomy X, also known as 49,XXXXX, is a chromosomal abnormality in which a female has five X chromosomes instead of the normal two.[2] Signs may include intellectual disability, short height, low-set ears, decreased muscle tone, and developmental delay.[1][2] Complications may include congenital heart disease.[3]"
"The condition is due to problems during the formation of the reproductive cells in a person's parents.[2] Risk factors include older parents at the time of conception.[2] Diagnosis is suspected based on symptoms and confirmed by chromosomal analysis
The aneuploidy is thought to be caused by problems occurring during meiosis, either in the mother or in both the mother and father. Successive nondisjunctions have been observed in the mother of at least one patient.[4][6]
The features of the syndrome likely arise due to failure of X-inactivation and the presence of multiple X chromosomes from the same parent causing problems with parental imprinting. In theory, X-inactivation should occur and leave only one X chromosome active in each cell. However, failure of this process has been observed in one individual studied. The reason for this is thought to be the presence of an unusually large, and imbalanced, number of X chromosomes interfering with the process.[6]"
XYYY
"48,XYYY syndrome is a rare Y chromosome number anomaly that affects only males and is characterized by mild-moderate developmental delay (especially speech), normal to mild intellectual disability, large, irregular teeth with poor enamel, tall stature and acne. Radioulnar stenosis and clinodactyly have also been associated. Boys generally present normal genitalia, while hypogonadism and infertility is frequently reported in adult males."
rarediseases.info.nih.gov/diseases/11985/48-xyyy
XXYY
en.m.wikipedia.org/wiki/XXYY_syndrome
"XXYY syndrome is a sex chromosome anomaly in which males have an extra X and Y chromosome. Human cells usually contain two sex chromosomes, one from the mother and one from the father. Usually, females have two X chromosomes (XX) and males have one X and one Y chromosome (XY). The appearance of at least one Y chromosome with a properly functioning SRY gene makes a male. Therefore, humans with XXYY are genotypically male. Males with XXYY syndrome have 48 chromosomes instead of the typical 46. This is why XXYY syndrome is sometimes written as 48,XXYY syndrome or 48,XXYY. It affects an estimated one in every 18,000–40,000 male births.[1]"
We can all Google to find others...
From a brief read, a lot, even though they have some issues, seem to be fine overall, and some not even know they have this. Some only know because of fertility issues.
Not all have fertility issues.
Not all with these conditions survive. Miscarriages, still births, deaths later on from heart conditions and other conditions. I read recently 98-99% of those with Turner's syndrome (X) don't survive to live birth for example, and others who do survive to birth later can have serious heart problems.
"Despite the excellent postnatal prognosis, 99% of Turner syndrome conceptions are thought to end in miscarriage or stillbirth"
en.m.wikipedia.org/wiki/Turner_syndrome
I have also read the majority with Turner's who survive have happy and healthy life.
I haven't looked up about survival of the other conditions, only wiki.
This is a word that keeps coming up
Aneuploidy
en.m.wikipedia.org/wiki/Aneuploidy