Any gender critical Armisted Maupin fans care for a chat about how this is treated in the books
three thoughts so far
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Anna Madrigal is anagram of A man and A girl. This makes Mona cross for obvious reasons
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When Jake (a transman) is cuddling the Mormon guy (who is gay but not out) - he does not want to have sex as does not link his gentalia with who is is
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Anna Madrigal seems fatherly to Mona