Has anyone with PCOS used orlistat to help with weight loss/management? How do/did you find it? I was diagnosed with PCOS over 20 years ago and have always managed to keep my weight in check, but since having DC (my youngest is 3), I've struggled to lose the weight. I've lost and gained the same stone more than once but can't seem to make any lasting progress. It's really effecting my self-esteem.