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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

The average weight loss on MJ is 20%, for those that have reached or close to goal has this been true for you?

35 replies

Jenasaurus · 26/04/2026 13:14

I have lost 40.8% of my weight, but am a slow loser as this is an average of 1.07 pounds a week over 78 weeks, so not sure where I would fall in this journey as over a longer time but I had weeks (many where I stayed the same, the only month I lost more was the first month where I lost 9 pounds) I had type 2 diabetes (now in remission), high cholesterol, (now normal) and fatty liver, now resolved, my BMI has gone from 34 to 21 at the age of 61 I feel healthy for the first time in my life. I had absolutely no side effects, apart from appetite suppression, and will stay on this for life.

Although Mine is over 78 weeks I lost the majority in the first 12 months and then am sort of going up and down each week as I maintain.

How has this been for you in the terms of percentage and side effects. According to a report those who felt the most nausea lost the most weight, which makes sense but a study carried out by 23andMe showed there was a connection with a gene and greater weight loss, the same gene makes you feel more sick, also makes you lose weight faster.

I consider myself a slow to average loser but I was fighting age related menopausal belly fat that was determined it had found a home for life, I am also quite sedentary since having metal work in one of my legs so, this loss was almost purely diet alone.

OP posts:
ButterYellowHair · 26/04/2026 16:30

SilenceInside · 26/04/2026 14:25

I'm not sure it's the same gene that's responsible for the nausea as the ones that are linked to slightly higher weight loss. The Guardian article has a summary of the findings:

https://www.theguardian.com/science/2026/apr/08/dna-could-help-explain-why-weight-loss-jabs-may-not-work

The relevant part is "They found that the GLP1 receptor variant rs10305420 was associated with slightly more weight loss in those carrying this variant compared with those who lacked it. Another variant, rs1800437, was associated with nausea and vomiting in people taking tirzepatide but was not associated with how much weight they lost."

The difference in weight lost was really small, only 0.76kg difference. The biggest indicator of how much weight you will lose is still sex and ethnicity, with women and those of European descent tending to lose the most weight.

I didn’t get any nausea and lost 30% still. I am a European heritage woman though.

Lardybumbum · 26/04/2026 16:32

I’m about 25% of bodyweight after a year. Aside from the first few months it’s mostly been 1lb a week and some weeks are up some down.

ButterYellowHair · 26/04/2026 16:32

crawlingovertheline · 26/04/2026 16:28

Gosh your stories are so inspiring. Excuse my ignorance here, but is it just the lack of eating /calories that causes the weight loss?

It’s mostly that yes. It’s a calorie deficit made easier by the drug which essentially mimics feeling full /satiated so the brain demands less calories so you eat less. Theres also some regulation of blood sugar that has a similar effect and some reduction in inflammation.

Twasasurprise · 26/04/2026 16:40

45% lost in a year, from BMI 38 to 21.

Willowy2 · 26/04/2026 18:55

I've lost 36.6% in under a year which was a 5 and half stone loss. I'm maintaining now. BMI 30 to 20.

Crunchymum · 26/04/2026 19:03

45% and I've just reached the one year mark.

susiedaisy1912 · 26/04/2026 19:03

2 years on MJ and I’ve lost 35% of my body weight. Most of it in the first 18 months.

Taxiparent · 26/04/2026 19:04

I have lost 41% of my weight over 60 weeks. That included a gain over a holiday and since then (6 months) I have gone down doses (came off for 1 month completely) gained 7lbs and now I’m back at my lowest. I haven’t had any sickness, the odd occasion where I have felt a wave of nausea for a moment, but that usually signals that I need to drink and then it goes immediately.

MeridaBrave · 26/04/2026 19:10

I started at 72kg and got to 58kg. So that’s 19%. But that took me to a weight that wasn’t really sustainable.

Fishingboatbobbingnight · 26/04/2026 19:16

I went from 95kg to 61kg so 35.8 % from April 24 to Jan 25. Titrated down from 15mg to 5mg between Jan and June 25 and maintain +/- 2kg on 5mg since then ..
BP now healthy no more meds
cholesterol in healthy zone no more statins
sleep apnea resolved no more awful CPAP machine.
inflammation markers all gone.

it is indeed miraculous. I have no intention of stopping. For me this is a health priority . I am 61 and have never been fitter since I was in my 20s .

I take Mounjaro.

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