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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Week 3 of weight and no weight loss

55 replies

jocktamsonsbairn · 28/01/2026 21:09

i’m bit concerned!! Have done 3 jabs now of .25 and although the ‘food noise’ has gone and I am definitely eating way less than I was before, I’m doing more exercise (started the gym etc) I haven’t lost any weight. Today for the first time since starting I have started craving snacks this evening and ate some crisps and chocolate. I don’t want to go down that slippery slope again!!
have ordered the 0.5 injections which should be with me soon. Should I forget dose 4 of 0.25 (I think I wasted some of it in the original pen as I absent minded twisted it before I put the needle in day of my first jab as I didn’t know what I was doing. I did then twist it round to .25 so not sure if I have myself extra that fist time which would leave less for the last one. ) and go onto .5 if the .25 isn’t stopping the snacking? Am gutted as had hope this would help and I’m not sure why I have t lost any weight as I’ve not eaten anywhere near the amounts I usually do. Have also changed my diet so it’s 99% good stuff! I am aware that muscles weigh more than fat and that o might be toning up but I do t think I’ve done enough in that area to make a difference.

Any ideas on what to do from now? Thanks.

OP posts:
jocktamsonsbairn · 29/01/2026 11:23

Thanks everyone! Yes it’s Wegovy. I had put it in the title but my phone changed it to ‘weight’ and I didn’t notice.

In the past whebwver I’d spent 2-3 weeks eating and drinking far less and cut out the snacking I would lose weight but this hasn’t happened!!
I am going to track the calories but as I said I put in everything from yesterday including the splash of milk in my morning coffee. Bearing in mind yesterday was the worst day so far and I was still under 1500 calories.

it’s giving me hope that other people felt the same and I know 0.25 is a very low dose so hopefully it will get better as I progress, it was just a bit demoralising to not lose anything when eating way less calories. I know I am eating far less as I know what I am eating compared to what I did before! Also drinking less wine! I will continue with the wine but less and only at the weekends as life is to be enjoyed!
Will track my calories too and see how that goes.

OP posts:
jocktamsonsbairn · 29/01/2026 11:29

Just done a couple of TDEE calculators and they have said I need 1934 calories a day for maintenance with a sedentary lifestyle and 2216 with light exercise so I am way under that if my worst eating day in 3 weeks was around 1400!

OP posts:
Alltheyellowbirds · 29/01/2026 11:36

jocktamsonsbairn · 29/01/2026 11:29

Just done a couple of TDEE calculators and they have said I need 1934 calories a day for maintenance with a sedentary lifestyle and 2216 with light exercise so I am way under that if my worst eating day in 3 weeks was around 1400!

Stick with it. I swear the one thing I have learned in all my years of trying to lose weight is that weight loss isn’t linear. Sometimes you stick at a weight for ages and see no change, then all of a sudden there’s a whoosh. I think that sometimes when you suddenly drop calories the body reacts to it in funny ways that might lead to holding onto water. Doesn’t mean you’re not still losing the fat in the background but it doesn’t show until the body lets go of the water too.

WeAllHaveWings · 29/01/2026 12:05

Many people under estimate their food calories and over estimate their exercise calories. If you don't measure it accurately, you can't manage it.

Your TDEE is around 1900. Cutting calories for 1lb loss a week would then be 1400. Don't eat back your exercise unless you are losing too quickly.

Use an app and weigh/measure and log all food and drink that passes your lips for a month to see if you are consistently keeping to your deficit. It will be annoying, but it may give you the insight you need.

HarvestMouseandGoldenCups · 29/01/2026 12:09

jocktamsonsbairn · 28/01/2026 22:16

Thanks. No I’d never add on the calories from exercise, I just mentioned it to say what the app said.
I’ve dieted for years and know roughly what amounts to have etc. I eat a pretty healthy diet normally (Mediterranean based) but it’s the snacking and the wine… it’s just that normally on plans like slimming world I would be losing weight by week 3 of no snacking and reduced meals but I haven’t on this.
I’ll keep going, reassuring to hear others have lost after a slow start too! Thanks for the encouragement!

Stop drinking alcohol while you’re on WLI. It defeats the point of them. It’s incredibly dense in calories, pauses all fat burning while the body metabolises the booze, means anything you eat with alcohol in your system is sent immediately to fat storage and increases cortisol (fat storage and inflammation).

You might as well throw that days dose out of the window.

farfallarocks · 29/01/2026 12:12

I still have the odd glass of wine on mounjaro and have lost a huge amount of weight. Can you try skipping breakfast, 2 meals a day and some fasting periods? To kick start it!

HarvestMouseandGoldenCups · 29/01/2026 12:20

farfallarocks · 29/01/2026 12:12

I still have the odd glass of wine on mounjaro and have lost a huge amount of weight. Can you try skipping breakfast, 2 meals a day and some fasting periods? To kick start it!

The odd glass of wine… op says wine and snacks are her issue so I assume she’s having more than a single glass every few weeks

HappyWineDay · 29/01/2026 13:08

HarvestMouseandGoldenCups · 29/01/2026 12:09

Stop drinking alcohol while you’re on WLI. It defeats the point of them. It’s incredibly dense in calories, pauses all fat burning while the body metabolises the booze, means anything you eat with alcohol in your system is sent immediately to fat storage and increases cortisol (fat storage and inflammation).

You might as well throw that days dose out of the window.

We must all be different because I've lost four stones, eat healthily and drink like a pirate. I haven't experienced any of the typical side effects of these WLIs.

jaelato1 · 29/01/2026 13:29

jocktamsonsbairn · 29/01/2026 11:29

Just done a couple of TDEE calculators and they have said I need 1934 calories a day for maintenance with a sedentary lifestyle and 2216 with light exercise so I am way under that if my worst eating day in 3 weeks was around 1400!

You are not eating under, you need to subtract 500 calories from your TDEE to lose weight, which is about 1400

ShawnaMacallister · 29/01/2026 14:00

HarvestMouseandGoldenCups · 29/01/2026 12:09

Stop drinking alcohol while you’re on WLI. It defeats the point of them. It’s incredibly dense in calories, pauses all fat burning while the body metabolises the booze, means anything you eat with alcohol in your system is sent immediately to fat storage and increases cortisol (fat storage and inflammation).

You might as well throw that days dose out of the window.

There's no need to stop all alcohol on WLI! Lots of people will be on the long term and there's no need to become teetotal. 2 measures of clear spirits with a diet mixer is 110 calories and fits perfectly well within a calorie deficit for most people!

WeAllHaveWings · 29/01/2026 14:23

HarvestMouseandGoldenCups · 29/01/2026 12:09

Stop drinking alcohol while you’re on WLI. It defeats the point of them. It’s incredibly dense in calories, pauses all fat burning while the body metabolises the booze, means anything you eat with alcohol in your system is sent immediately to fat storage and increases cortisol (fat storage and inflammation).

You might as well throw that days dose out of the window.

So apparently one drink and my body immediately halts all metabolism, sends my dinner straight to fat storage, and panics hormonally?

Back in reality, metabolism is far less dramatic.

farfallarocks · 29/01/2026 14:26

Yes I drink probably 3 nights a week, 2-3 glasses of wine so not the odd glass. I’ve lost 4 stone in 4 months ! BMI now actually 19 so need to come off slowly

farfallarocks · 29/01/2026 14:27

I would say my diet is all whole
foods, balanced and no snacks or UPF though

HarvestMouseandGoldenCups · 29/01/2026 14:27

WeAllHaveWings · 29/01/2026 14:23

So apparently one drink and my body immediately halts all metabolism, sends my dinner straight to fat storage, and panics hormonally?

Back in reality, metabolism is far less dramatic.

Yeah that’s literally what alcohol does… the body diverts metabolic processes to eradicate the poison first before using any of the other things you’re ingesting for ATP (energy) production. And alcohol stimulates cotisol production…it acts as a trigger for the endocrine system to make more of it.

One glass may not feel like it has an effect but for the 2-3 hours you have it in your system it is doing these things.

HarvestMouseandGoldenCups · 29/01/2026 14:28

HappyWineDay · 29/01/2026 13:08

We must all be different because I've lost four stones, eat healthily and drink like a pirate. I haven't experienced any of the typical side effects of these WLIs.

Edited

I didn’t say you couldn’t lose weight but it’s definitely reducing your ability to. You’d have lost weight faster without drinking and at £160-300 a month it seems a bit redundant to risk that with alcohol.

Youre also missing the fact that OP ISNT losing weight and says wine is a part of that.

HarvestMouseandGoldenCups · 29/01/2026 14:42

farfallarocks · 29/01/2026 14:26

Yes I drink probably 3 nights a week, 2-3 glasses of wine so not the odd glass. I’ve lost 4 stone in 4 months ! BMI now actually 19 so need to come off slowly

Well you should stop that for other reasons too - you’re having up to 27 units a week. Recommended max is 14. It’s your choice obviously but I don’t know why you’re all arguing with me that drinking alcohol isn’t bad for both your weight and health.

If OP isn’t losing weight and wants to the alcohol is an obvious place to start.

farfallarocks · 29/01/2026 14:45

There is a good pod cast on Zoe re alcohol it’s not as simple as it just being bad for health. If you look at it holistically in the context of longevity, benefits of socialisation etc

WeAllHaveWings · 29/01/2026 14:53

HarvestMouseandGoldenCups · 29/01/2026 14:27

Yeah that’s literally what alcohol does… the body diverts metabolic processes to eradicate the poison first before using any of the other things you’re ingesting for ATP (energy) production. And alcohol stimulates cotisol production…it acts as a trigger for the endocrine system to make more of it.

One glass may not feel like it has an effect but for the 2-3 hours you have it in your system it is doing these things.

I am not disagreeing with parts of your post, alcohol certainly is not weight loss friendly, but you must admit you are exaggerating the point.

Yes, the body processes alcohol first because it can’t store it, but that doesn’t mean it stops doing everything else. Other normal functions, including using carbs/fats for energy are still happening. It is a temporary shift in priority not a shutdown of processing anything else.

Alcohol is processed fairly quickly, about one standard drink per hour, so a single glass is usually out of your system in roughly 1–1.5 hours. During that time, its effects gradually taper off rather than staying constant the whole time and fats and carbs are being processed.

As for cortisol, alcohol can raise stress hormones, but that’s usually with larger amounts. One drink doesn’t cause a big or lasting hormonal response in most people. So yes, alcohol has effects while it’s being processed, but one glass isn’t a dramatic disruption, it’s minor, temporary, and the body keeps doing its other jobs the whole time.

HarvestMouseandGoldenCups · 29/01/2026 15:00

WeAllHaveWings · 29/01/2026 14:53

I am not disagreeing with parts of your post, alcohol certainly is not weight loss friendly, but you must admit you are exaggerating the point.

Yes, the body processes alcohol first because it can’t store it, but that doesn’t mean it stops doing everything else. Other normal functions, including using carbs/fats for energy are still happening. It is a temporary shift in priority not a shutdown of processing anything else.

Alcohol is processed fairly quickly, about one standard drink per hour, so a single glass is usually out of your system in roughly 1–1.5 hours. During that time, its effects gradually taper off rather than staying constant the whole time and fats and carbs are being processed.

As for cortisol, alcohol can raise stress hormones, but that’s usually with larger amounts. One drink doesn’t cause a big or lasting hormonal response in most people. So yes, alcohol has effects while it’s being processed, but one glass isn’t a dramatic disruption, it’s minor, temporary, and the body keeps doing its other jobs the whole time.

The body processes alcohol at 1 UNIT per hour… not one drink. Not unless it’s a 25ml spirit and mixer. A standard glass of wine takes just over 2 hours, a 250ml glass takes 3 hours. So you’ve misunderstood or misrepresented that aspect already.

And I never said that moderate drinking causes a big or lasting hormonal response but one drink does stimulate cortisol production. Alcohol is a toxin/stressor and even one glass might activate the HPA Axis to release a spike of cortisol.

And yes I am passionately anti-alcohol as I honestly think it is shit for health. But as I’ve said, it’s personal choice. If you think I’m exaggerating then that’s your prerogative.

HarvestMouseandGoldenCups · 29/01/2026 15:03

farfallarocks · 29/01/2026 14:45

There is a good pod cast on Zoe re alcohol it’s not as simple as it just being bad for health. If you look at it holistically in the context of longevity, benefits of socialisation etc

Zoe shares an opinion on alcohol. It doesn’t apply to everyone and I certainly don’t think it should convince you that alcohol is anything except a toxin to your body just because it makes you happy sometimes to have a glass with a mate.

As I’ve said multiple times on this thread - it’s personal choice to drink or not. OP wants to lose weight and isn’t. So stopping drinking would help her to achieve her goal.

Tammy214 · 29/01/2026 16:47

I find it funny that someone askes a question and all of a sudden there is an influx of posts fixating on what 'awful' habit. if you are in deficit calories wise it doesnt matter where those come from, you will lose weight.
Alcohol is often seen as empty calories, yes we all know about the downsides, but also some people like it and make compromises to enjoy a tipple.
My partner has been swimming, walking and mostly not drinking, and has lost a minor amount, however his body shape has changed, you can see he is losing weight (trousers looser etc) but the scales dont reflect it.

However a few weeks of not losing weight could simply be delayed losses, especially at the start of the journey, it could catch up with you .

TheChosenTwo · 29/01/2026 17:55

I’ve not calorie counted at all, not one single day. And I’ve lost rather a substantial amount of weight, I think I might be a super responder as I lost my appetite within hours and lost 3 stone in the first 3 months. I was heavy though, 16st with a BMI of 35 so drastically overweight.
15 month in, 6.5 stone down and I still don’t count calories, just eat twice a day, a salad for lunch (with a dressing) and a small dinner. Maintaining my weight no longer losing.
However lots of people do say they don’t lose weight at all until they’ve moved up a dose or two so while it’s easy to become disheartened I think it’s worth carrying on for a bit at least.
Of course there are also some who are completely unaffected by the medication and I don’t know how long I’d be prepared to pay for with no shift in the scales (of course that’s exactly what I’m doing now but the scales are showing me I’m at a healthy weight so the price for me is worth it.

Disturbia81 · 29/01/2026 18:10

TheChosenTwo · 29/01/2026 17:55

I’ve not calorie counted at all, not one single day. And I’ve lost rather a substantial amount of weight, I think I might be a super responder as I lost my appetite within hours and lost 3 stone in the first 3 months. I was heavy though, 16st with a BMI of 35 so drastically overweight.
15 month in, 6.5 stone down and I still don’t count calories, just eat twice a day, a salad for lunch (with a dressing) and a small dinner. Maintaining my weight no longer losing.
However lots of people do say they don’t lose weight at all until they’ve moved up a dose or two so while it’s easy to become disheartened I think it’s worth carrying on for a bit at least.
Of course there are also some who are completely unaffected by the medication and I don’t know how long I’d be prepared to pay for with no shift in the scales (of course that’s exactly what I’m doing now but the scales are showing me I’m at a healthy weight so the price for me is worth it.

Don’t you think it’s better to get into the habit now for when you come off?

PinterandPirandello · 29/01/2026 18:20

The weight loss injections don’t work for everyone scientists have found.

TheBroonOneAndTheWhiteOne · 29/01/2026 19:23

I've never counted calories either and I've lost 9st 5lb in two years.
I've got about 14lb to go to get to a healthy BMI.

I very rarely drink alcohol. Just had two glasses of wine on Christmas Day and nothing the rest of the year.