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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

What happens when people stop the injections?

162 replies

IndigoBluey · 30/11/2025 01:18

Just this really, when you reach your desired weight following the course of weight loss injections, do you stop taking the injections whilst sticking to a much healthier way of eating? I’m genuinely curious as to how it works in the long term. A friend of mine had stomach surgery a few years ago to shrink her stomach and very rapidly went from 18 to 9 stone, but then put a lot of weight back on gradually, to then start on WL injections. I suppose my question is when you know you are finished with needed the injections?

OP posts:
TheRealGoose · 05/12/2025 14:24

KilliMonjaro · 05/12/2025 12:59

See this isn’t about weight then is it? How do we deal with inflammation once we come off?

It’s about many things, but primarily health.

inflammation is basically ageing as we live our lives our cells suffer damage, as much as we recover, cold, flus, viruses, etc, our cells always carry the marker of this, and that’s what ageing is.

when you remove the inflammation, then our cells regenerate, and that’s why they now think the meds are anti ageing, our cells can’t full regenerate with the inflammation, and now studies are about to be done into the fact the drugs either slow down, stop or in some reverse ageing. Not our face, that’d collagen, but our organs.

when your weight is lower, your metabolism should be better, any metabolic issues reduced, and as such inflammation will not be as severe unless you have issues ie arthritis.

there are no drugs I’m aware of to deal with inflammation specifically that you can buy, so it’s down to diet as a pp said, and a healthy lifestyle, exercise, hydration etc, you can google it.

or you can stay on a low therapeutic dose of the drugs, I am, inflammation really isn’t my concern as such, I want to maintain this weight, as i was unwell heavy, high blood pressure, sleep apnea, high cholesterol, as well as high cortisol due to menopause causing many of the issues, I can’t go back there, so for me I’m staying on, I also don’t want to live my life constantly trying to manag3 my weight and failing, and I will fail , be it in a year or five, there is no point pretending otherwise. I also want all the health benefits of the drugs, improved cardio vascular, kidney and liver function, reduction in some cancers, potentially even staving off dementia.

so for me appearance was a cherry on top. As much as it is lovely to be slim again, it is much much more important to be healthy,

coming off or staying on is a personal choice, one made with a lot of different factors, not least cost, and I’m choosing to stay on. Everyone has to maw their own decisions,

MeridaBrave · 05/12/2025 16:16

I only ever took 2.5mg but I have decided to titrate down slowly. I have a lifetime of disordered eating / gaining and loosing weight so I want to make sure my weight now is sustainable.

i’m eating lots of protein, and mainly follow a whole foods anti inflammatory Mediterranean diet. I know my inflammation is lower than it was as I have less joint pain / niggles.

I’m lifting heavy weights every day.

That all being said I might microdose long term just need to work out what the microdose looks like, currently 2mg a week.

Fatmumslim01 · 05/12/2025 17:31

MJ has changed my life. I've lost almost 50 pounds with another 30 at least to go but it's the non weight loss benefits that have blown my mind and part of the reason I want to stay on MJ or similar very long term.

Non weight loss benefits include
Eczema gone when steroid cream couldn't shift it

Lighter periods, I need less prescription painkillers on my period now

I need less thyroxine (I have under active thyroid)

Plantar fascitis went within the first month so can't be down to weight loss

Recurring mouth ulcers stopped and I haven't had one for 9 months

Early stage gum disease needing £70 hygienist treatment every 3 months has gone

Chronic pain due to pelvic adhesions disappeared, pre mounjaro I was thinking of having surgery but no longer needed

My head is just calmer, I'm less anxious, more organised, more productive etc

It's absolutely a miracle drug!

hnwis · 05/12/2025 19:02

MeridaBrave · 05/12/2025 16:16

I only ever took 2.5mg but I have decided to titrate down slowly. I have a lifetime of disordered eating / gaining and loosing weight so I want to make sure my weight now is sustainable.

i’m eating lots of protein, and mainly follow a whole foods anti inflammatory Mediterranean diet. I know my inflammation is lower than it was as I have less joint pain / niggles.

I’m lifting heavy weights every day.

That all being said I might microdose long term just need to work out what the microdose looks like, currently 2mg a week.

How do you take a lower dose? Im
interested in doing this.. thanks

MeridaBrave · 05/12/2025 19:27

hnwis · 05/12/2025 19:02

How do you take a lower dose? Im
interested in doing this.. thanks

I’m taking 24 clicks from a 5mg pen. It will last beyond 30 days but I keep it in the fridge and can live with the risk. Could use a 2.5mg pen it would be 48 clicks.

hnwis · 05/12/2025 19:29

@MeridaBraveso you click 24 times & then inject, then put back in fridge & next time do the same? Does that give you an extra dose out of the pen then?

PapaSatanicus · 05/12/2025 22:00

For the record there are many ways to lower inflammation. For example Statin drugs are very effective at reducing inflammation, so is an Alpha Lipoic Acid supplement and so is exercise.

Given that weight loss injections work by reducing blood sugar; if you want to stay slim when off the injections and not put the weight back on you need to be on a healthy low carb or keto diet to keep your blood sugar low if you do not do significant exercise. If you don’t change your diet and lifestyle you will put the weight back on.

Going low carb or even better, keto, will fix a broken metabolism (train your body to use fat as an energy source as a glucose alternative) meaning you can gradually increase the carb intake some.

Low carb or keto will also mean you are less hungry - same as the injections - because they also lower blood sugar.

TheRealGoose · 05/12/2025 22:21

PapaSatanicus · 05/12/2025 22:00

For the record there are many ways to lower inflammation. For example Statin drugs are very effective at reducing inflammation, so is an Alpha Lipoic Acid supplement and so is exercise.

Given that weight loss injections work by reducing blood sugar; if you want to stay slim when off the injections and not put the weight back on you need to be on a healthy low carb or keto diet to keep your blood sugar low if you do not do significant exercise. If you don’t change your diet and lifestyle you will put the weight back on.

Going low carb or even better, keto, will fix a broken metabolism (train your body to use fat as an energy source as a glucose alternative) meaning you can gradually increase the carb intake some.

Low carb or keto will also mean you are less hungry - same as the injections - because they also lower blood sugar.

Statins? No one is going on statins to reduce inflammation and low carb is absolutely nothing like being on the meds, trust me, I’ve done both.

1clavdivs · 06/12/2025 11:22

PapaSatanicus · 05/12/2025 22:00

For the record there are many ways to lower inflammation. For example Statin drugs are very effective at reducing inflammation, so is an Alpha Lipoic Acid supplement and so is exercise.

Given that weight loss injections work by reducing blood sugar; if you want to stay slim when off the injections and not put the weight back on you need to be on a healthy low carb or keto diet to keep your blood sugar low if you do not do significant exercise. If you don’t change your diet and lifestyle you will put the weight back on.

Going low carb or even better, keto, will fix a broken metabolism (train your body to use fat as an energy source as a glucose alternative) meaning you can gradually increase the carb intake some.

Low carb or keto will also mean you are less hungry - same as the injections - because they also lower blood sugar.

Also for the record, lowering blood sugar is not the only way WLIs work. That’s just one of the effects. I did Keto for a long time and yes I did feel less hungry and out of all the diets I did it suited me the best, but I lost very little weight on it. Like every other diet I did, I lost half a stone then stalled. I lost more on Weight Watchers. Trust me, the efficacy of WLIs is entirely different.

TheRealGoose · 06/12/2025 13:14

1clavdivs · 06/12/2025 11:22

Also for the record, lowering blood sugar is not the only way WLIs work. That’s just one of the effects. I did Keto for a long time and yes I did feel less hungry and out of all the diets I did it suited me the best, but I lost very little weight on it. Like every other diet I did, I lost half a stone then stalled. I lost more on Weight Watchers. Trust me, the efficacy of WLIs is entirely different.

I also did keto for years and low carb, it is incredibly difficult to maintain it for most people. We even see it on the boot camps on here, peiple coming back time and time again, it’s ultimately about calories in v calories out like every other diet inc weight loss med support, and yes you do get less hungry and your blood sugar doesn’t spike, but it doesn’t come within a mile of what weight loss injections do. It’s not even in the same ballpark and it’s an incredibly difficult way to live day in day out. It can also cause health issues where people start to put too much fat into their diet, as really whay it is is high fat, medium protein and low carb proportionally as your total cals.

So you see people swathing stuff in butter, adding cream and cheese to everything, and simply not following a healthy diet,

TaffyTabby · 06/12/2025 13:27

Keto can be problematic due to higher fat diets putting you at higher risk of gallbladder problems and therefore higher risk of pancreatitis.

dontletmedownbruce · 06/12/2025 13:37

I have only had four pens over six months - all at the lowest dose (2.5mg). I’ve lost all the weight I wanted / needed to, and brought my BMI back down to 22.5

i intend to continue with the 2.5mg pen so long as my dispenser is willing to supply it, and inject every other week rather than every week.

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