Titrating UP Mounjaro 2.5ml

[Terry2025]

Hi :)

I have 2 pens of 2.5ml but i need to increase my dose.
I have read not to take more than 1 dose at one time.
So, my plan is to take 2.5ml Monday & 1.25ml Thursday so I am leaving a clear 72 hours between injections.

Has anyone used this approach successfully?

Has anyone injected more than 1 dose from a pen in one go?

Any feedback/comments welcome

thank you

Have you done 4 weeks on the 2.5mg (not ml) dose? Is there a reason that you want to do a 3.75mg dose rather than a 5mg one?

I have absolutely no idea what you are trying to ask.

I mean, very few people will have decided to ignore the standard dose schedule and do a split dose where you’re injecting twice in a week. There’s no need to do that, or reason to try it, for most people.

Perhaps you could explain why you want to do a split dose and why you want to try 3.75mg in a week rather than just move up to the 5mg dose. And why you decided to order several 2.5mg pens to start with?

Wow the helpful people are out in force today!

It's perfectly clear the OP wants to take 3.75ml and she rightly knows she has to wait 72 hours between injections.

OP - ignore the people trying to make themselves feel good by being unhelpful to you.

I have taken mj less than 7 days apart just fine for pretty much the duration. I wouldn't personally take different doses on different days. Equally it's a personal view only but I wouldn't want to do 2 doses one after.

I am super sensitive to glp1 and worked out my best intake through https://glp1plotter.com/
You may want to try taking doses in the second month every 5 or 6 days instead of 7.

You can obviously do whatever you want but think carefully about the guidelines that exist for a reason.

She really doesn’t want to take 3.75ml, that would be a huge amount of medication to take above the usual 0.6ml dose. She wants to take 3.75mg, which from a 2.5mg pen would be 0.9ml using a separate syringe, or a standard 60 click injection plus a second 30 click injection if using the pen.

You could do 90 clicks on a 2.5mg pen instead of 60 clicks.

Well most people would have just realised I meant mg. A key difference obviously...

Yes, you’re right there’s a big difference between ml as a measure of volume and mg as a measure of strength. Especially when discussing doing non-standard dosing schedules and doses. Best to be clear about what you mean.

I’d do the 90 clicks. It would be 2 injections on the same day but should be ok.

i went to 5mg but had a month of 3.75 and im glad i did.

Yes, you can take more if you choose to.
However, you should stay on a dose for at least 4 weeks before increasing it.

I had been on the same dose for a few months but realised I needed to move up a dose, ordered a pen in the next dose up, but used the current pen to give me an increased dose. You can do this in 2 ways.

1. turn the pen the full 60 clicks as usual (to the no. 1), inject. Keep the needle in you, turn the pen the required number of clicks and press down again. That is the way I do it.
2. Or, do the full dose as usual, take the pen out, change to a fresh needle. prime it and then count clicks before injecting again.

You do not need to do separate doses on separate days.

This chart explains how many clicks you need for a dose out of particular pens.
(If you need to use a separate syringe as you are using the 'golden dose, then it is gives you the amount in ml's)
I hope that makes sense, but ask questions if not and we will try and clarify.
monj.co.uk/monj-mounjaro-click-chart/

I did my first month on 2.5mg and felt I needed to go straight to 5mg. At dose 4 from that first pen I took the 4th dose and extracted the "extra" dose with a syringe at the same time, giving a 5mg total.
No issues whatsoever. I see no reason why you can't do two doses at the same time. Do it in a different place.

If you have already taken 4 doses of 2.5mg then it’s fine to take 3.75mg on the same day. Re: splitting it, might make sense if the suppression drops later in the week but not sure it’s necessary otherwise.

I did 72 clicks today from a 2.5mg. 3mg seems to be my sweet spot currently.

I do have insulin needles for when my clicks run out but my liquid doesn't.

OH GOSH! i did not mean to cause so much trouble!

In my attempt to keep my question brief i excluded what is clearly key information

I had horrendous SE with Wegovy last year - it made me very ill with chronic constipation which i have to manage every day with dietary choices.

So, I started Mounjaro end of May very slowly and did a snails pace rise to a weekly 2.5ml dose

I found this both a manageable and effective dose until early last week when I began to realise the "flattening" of the effect and began thinking of increasing my dose. Unfortunately only 48hours before this i had ordered 2 x 2.5ml pens on a special offer so I have them to use up. Clearly, i will going forward order 5ml pens!

Hope this has cleared up all questions

Really appreciate all feedback x

mg not ml….

If you feel 3.75mg is the dose you want to try, then I’d do a 2.5mg normal dose from your 2.5mg pen, and also a 30 click half dose for 1.25mg with a new needle from the same pen at a different injection site. On the same day.

Hi
thanks so much for that link - Ive been using the SHOTSY app to monitor my levels and you are correct that i am "super-sensitive" to the effects of GLP1

Thanks also for the idea of splitting them equally - don't know why i didn't think of that!! I will try 45 clicks twice a week = 90 clicks = 3.75mg and see how i get on

thank you for correcting me on the ml/mg x

Thanks, i will try that next week/ week after and see how i get on - if SE manageable then may as well just do it at the same time i suppose

thank you thats really helpful and the link to the click chart

I wouldn't inject more than once a week on a regular basis. The 7 day dosing schedule is there for a reason.

There are more unknowns to consider with more frequent dosing than what shows on a pretty graph.

The 72 hours between injections in the instructions is for occasional exceptions, not for armchair pharmacologists to run experiments on themselves.

I would do as @SilenceInside suggested and take 3.75mg once a week. Sensible and low risk.

If it's a case of you were ready to move up and have done the minimum 4 wks but have a 2.5 pen to use up, then personally I would inject the dose you want all at once,
I didn't know you weren't supposed to inject twice (as long as total dose is ok) and have done that before when I have a half dose left in a pen.

You can either do it by counting clicks or drawing out the whole dose in a syringe, just if you do that be very careful about dosage.

I'm not recommending you do 3.75mg twice a week. That'd be a helluva increase! You could have tried 1.8mg every 5 days for example. I would map this out on the plotter so you can see what the dose looks like.

If I were you I'd get some syringes and draw out the equivalent of 3.75mg (0.9ml) once a week. You'll need some syringes if you want to get the bonus doses in any event.

Not 3.75ml, blimey. On any strength pen, 3.75ml would be a lot. From a 2.5mg pen, you would need 0.9ml for a 3.75mg strength dose.

Christ you must have been watching this every second to see that typo. So weird! You'll see that's what I was writing anyhow.

Yep, constantly monitoring you, clearly. Glad you subsequently edited to correct the error.