Meet the Other Phone. A phone that grows with your child.

Meet the Other Phone.
A phone that grows with your child.

Buy now

Please or to access all these features

Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Piling the weight back on when stopping MJ

632 replies

Richtea67 · 15/05/2025 19:10

Hi all....I'm so disappointed. I lost 3 and a half stone, have been off injections for a month and regained nearly 7lbs 😩. I was a slow loser (1-2lb per week) and focused on changing habits and reducing portion size rather than diets/calorie counting (this has led to binging previously). I have kept up with a lot of the habits (smoothie for breakfast, cutting out alcohol and healthy high protein snacks). But portion sizes have definitely gone up as I'm hungrier! And I've been more tempted by the biscuits at work and the kids treats! Any advice?? I'm considering re starting if I put too much weight on, but financially this would be a struggle, which is part of the reason I came off them. My starting weight was 14.5 stones, weight when stopping injections 11 stones and at present nearly half a stone back on!! Help!

OP posts:
Thread gallery
10
BurnoutGP · 17/05/2025 10:41

blubbyblub · 17/05/2025 07:49

It’s hardly some revolutionary statement that requires a cited thesis.

the medications are an external moderator of appetite. People eat way way less than they used to

some people learn a lot through the process. They realise how little food they require compared to what they ate before. They relearn what a portion size for them actually looks like. They adopt new way of eating. Whether they choose to weight out portions or whether they are able to know going forward that a portion to sustain them is actually a third of what they used to eat, they learn through the experience of being on a WLI what food quantities they need to be eating to stay lean?

if a person continues to eat off the WLI as they did on the WLI then they will remain lean. If they revert to what they used to eat then they will regain.

its not the same as move more eat less. It’s understanding that the WLI affects the receptors in your brain that tell you that you are full. If people learn through using them just how little discrete require and continue to adopt this after WLI then they will remain slim.

Edited

Why do you post in these threads? Does it make you feel morally superior? Is it because God forbid those fatties you look down on might be able to change their lives. If I could have "learnt" to stick to healthy portion size and food then at the age of 54 with 2 medical degrees you might think I would have done so right?? Why haven't I ? Why did my BMI get to 46? Do you truly believe i am just too stupid/lazy/ignorant etc to just not bother??

SuperTrooper14 · 17/05/2025 10:42

blubbyblub · 17/05/2025 07:49

It’s hardly some revolutionary statement that requires a cited thesis.

the medications are an external moderator of appetite. People eat way way less than they used to

some people learn a lot through the process. They realise how little food they require compared to what they ate before. They relearn what a portion size for them actually looks like. They adopt new way of eating. Whether they choose to weight out portions or whether they are able to know going forward that a portion to sustain them is actually a third of what they used to eat, they learn through the experience of being on a WLI what food quantities they need to be eating to stay lean?

if a person continues to eat off the WLI as they did on the WLI then they will remain lean. If they revert to what they used to eat then they will regain.

its not the same as move more eat less. It’s understanding that the WLI affects the receptors in your brain that tell you that you are full. If people learn through using them just how little discrete require and continue to adopt this after WLI then they will remain slim.

Edited

WLIs influence brain receptors while you're taking them, they don't alter them. What you're talking about is creating new neural pathways that forge new healthier habits. The problem is, that's really, really hard to do when you're on the drugs because the very thing they do is stop you thinking about food and eating. So, if you're not thinking and embrace switching off from the food noise, you're not going to create new neural pathways.

SuperTrooper14 · 17/05/2025 10:43

BurnoutGP · 17/05/2025 10:41

Why do you post in these threads? Does it make you feel morally superior? Is it because God forbid those fatties you look down on might be able to change their lives. If I could have "learnt" to stick to healthy portion size and food then at the age of 54 with 2 medical degrees you might think I would have done so right?? Why haven't I ? Why did my BMI get to 46? Do you truly believe i am just too stupid/lazy/ignorant etc to just not bother??

That poster is simply incorrect in what they're saying too.

MoodSwingSet · 17/05/2025 10:45

CyclingAddict · 17/05/2025 10:33

There can be a genuine feeling of hunger ..stomach rumbling..feeling a lack of energy/headache...knowing that it’s been 6-7 hours since we have last eaten . A human need in order to survive !

Embracing those feelings of hunger..NOT TO PANIC !

Do we eat to live or live to eat?

People who are 'labradors', so to speak, live to eat. And now we have established that, then what? Oh just change your genes?

Oblomov25 · 17/05/2025 10:55

Watching with interest.

Sundews · 17/05/2025 11:20

LosingMyPumpkins · 16/05/2025 14:14

Isn't the research on fasting sort of iffy when it comes to women / concerning women in particular? I tried it and my cycle went completely erratic even though I wasn't undereating...
I absolutely agree with your point about protein. Fibre is also incredibly important when it comes to satiety.

Yes I’ve been reading Dr Stacey Sims new menopause book and a lot of the fasting studies have been done on men. She especially does not recommend women fast before exercise.

AmythestBangle · 17/05/2025 11:29

It's interesting how many people without any specialist knowledge, either by personal experience or by profession, come on threads about these particular treatments, when I am sure they wouldn't be offering their pearls of wisdom on support and discussion forums related to any other conditions and their treatments.

Richtea67 · 17/05/2025 11:34

Blomama · 17/05/2025 10:39

Could you try a low dose like 2.5, once a week. You can buy a 5mg pen and use half a dose (30 clicks rather than 60). That halves the cost and makes it a bit more affordable.

Thank you yes I may consider this...maybe then increase to 5mg and taper down from.there very gradually. I'm away next week so will have a weigh in after that and re assess. I'm definitely eating much more mindfully now....it was just so freeing on MJ with all that food noise gone. I'd forgotten what it was like to live with.

OP posts:
TheNinthLock · 17/05/2025 11:48

Slimfornow · 16/05/2025 18:14

People are obsessed with the idea that people who are overweight are that way because of mental/emotional issues. Do they also think whippets are simply more well balanced than famously uptight and unhappy (yes I’m being ironic) labradors? The difference between them is genetic.

There was an article in the papers (cant remember where) but it did indeed say that labradors are predisposed genetically to weight gain versus other dogs and that this same gene had been discovered in humans.
I remember joking to my dh that I was indeed a labrador.

Trabbling · 17/05/2025 11:51

SuperTrooper14 · 16/05/2025 07:45

Read up on The Ancel Keys experiment, Those men were on 1,600 calories a day.

https://psychiatry.duke.edu/blog/starvation-experiment

I'd never come across that before, thanks @SuperTrooper14 - fascinating stuff, and very worrying in the context of WLI restricting people's food intake to such an extent.

Starvation experiment

The Starvation Experiment

How Starvation Affects the Body and Mind

https://psychiatry.duke.edu/blog/starvation-experiment

TheNinthLock · 17/05/2025 11:54

TheNinthLock · 17/05/2025 11:48

There was an article in the papers (cant remember where) but it did indeed say that labradors are predisposed genetically to weight gain versus other dogs and that this same gene had been discovered in humans.
I remember joking to my dh that I was indeed a labrador.

Apologies, I see somebody already mentioned this, and managed to link to the article.

SuperTrooper14 · 17/05/2025 12:17

AmythestBangle · 17/05/2025 11:29

It's interesting how many people without any specialist knowledge, either by personal experience or by profession, come on threads about these particular treatments, when I am sure they wouldn't be offering their pearls of wisdom on support and discussion forums related to any other conditions and their treatments.

Isn’t that the problem though? Because these injections are being embraced as a new diet plan:aid it’s easy for people to forget that they’re actually a medication first and foremost. That’s glossed over in discussions.

Crikeyalmighty · 17/05/2025 12:43

@AmythestBangle sadly certainly didn’t work like that for me - felt like I wanted to smoke more due to eating less -

aylis · 17/05/2025 12:51

People trying to lose weight with massive calorie deficits isn't new or specific to Mounjaro/Ozempic. Calorie trackers often default to 1200 calories regardless of your height and weight, and then people feel encouraged to go lower for a bigger deficit. 1200 calories isn't sufficient for very overweight and obese people.

Might be an indication of how NHS support would be helpful to monitor the levels of appetite suppression as if someone is consistently unable to eat enough to subsist then they may be on the wrong dose.

Slimfornow · 17/05/2025 13:22

hehehesorry · 16/05/2025 23:57

You're not selectively bred to have a thick layer of fat to withstand water and knee high grass full of dew for 4-6h, you just eat too much. Europeans hold more fat around their midsection than most Asians as a rule (similar to your dog analogy), but it's not a matter of hanging stomachs and chafing thighs. It's like saying this dog is like this because of genetics, when it just eats too much.

And why do you think that dog eats too much while whippets don’t? HUNGER! People with ‘bad’ genetics (that would have conferred a survival advantage in a world of food scarcity) are hungry. Not greedy, stupid or weak-willed - just more lab than whippet. On the same number of calories as a smug thin person, they may wake up in the night because they are ravenous & never really feel satisfied. Few people can voluntarily live like that. In the past people would have their jaw wired shut to try to lose weight or eat tissues to fill their bellies. People used to chain smoke to squash hunger and stay slim. GLP-1s are a far, far better alternative!

ForeverDelayedEpiphany · 17/05/2025 13:55

SuperTrooper14 · 17/05/2025 12:17

Isn’t that the problem though? Because these injections are being embraced as a new diet plan:aid it’s easy for people to forget that they’re actually a medication first and foremost. That’s glossed over in discussions.

Exactly. I said in another thread that I am more worried about the long term impact and implications of a medication, tested but not known about how the body may be affected. I've had long term effects from a medication (antipsychotic) which i know is totally different, but i still think it's good to be a bit cautious sometimes.

Sundews · 17/05/2025 14:33

I would really recommend this YouTube / podcast by The Doctors Kitchen with Johan Hari who has written a book about WLI. They discuss the pros and cons in detail.

YouTube link

Spotify link
https://open.spotify.com/episode/1FWRQvbC8meONveAT9EMTE?si=6D--bNkKRHSq2kXJ7eQVsg

I have a BMI of 30 and am a size 14 so fall into the ‘obese’ category. My main concerns are the health implications of being obese. I have been debating WLI and found this really informative.

I only became overweight in the last 5 years (3 pregnancies, menopause, desk job). In my childhood and 20s I never really thought about my weight or what I ate and stayed a healthy size (8-10). So what has changed?

After listening to this I realise that I really need to look at the reasons why I overeat. For me it’s a sweet tooth and snacking.

- YouTube

Enjoy the videos and music that you love, upload original content and share it all with friends, family and the world on YouTube.

https://youtu.be/BAY_PYipz2U?si=N2iby8i9f_su48dC

liann34 · 17/05/2025 14:46

@SuperTrooper14the market is too huge and complex to pick out a couple of items and sat that's the worst, but the principles are fairly commonsense really. Humans are true omnivores and can live pretty well on a wide variety of diets, but the further away a food product is from its natural state the more likely its been manipulated in ways that are...experimental at best, proven harmful at worst. Artificially removing the fat from natural foods and replacing it with sugars and flavourings has generally been a failed experiment. A lot of UPF is also artificially low in fiber. Consider the difference between porridge made from whole oats and whole milk and a bowl of something like Krave. Some people would be driven to overeat either, and they are likely to be the people who really do have "hungry" genes, but most people would overeat the latter. Its designed to make you overeat it. The portion size is unrealistically low so they can fudge the nutrition stats, but they know what they're doing.

Sundews · 17/05/2025 14:52

@liann34 yes in the podcast I linked to they discuss UPFs and in experiments on rats if they were fed on a natural food diet they didn’t overeat but if they were fed on a typical American diet of UPFs, fried chicken, cheesecake etc they over ate and became obese and developed health problems.
Certain processed foods have been designed to overcome our natural feelings of satiety.

Sundews · 17/05/2025 15:02

So really WLIs are fixing a problem that was created by the food industry in the first place….

liann34 · 17/05/2025 15:34

@Sundews well I don't know about caused - but certainly exacerbated and profiteered from. And so much of the neurological and biological groundwork is laid in childhood. Of course as kids in the 90s we thought it the gravest injustice that our friends got Findus crispy pancakes and chips and we got curry rice and greens, but my God, for whatever else my parents got wrong, how right they were on that.

Sunshineandpool · 17/05/2025 16:53

AgathaMystery · 15/05/2025 22:00

I didn’t see your post before you edited.

The reason I wrote what I wrote is because anything else is pure gaslighting. I’ve participated in a GLP clinical trial AND I’ve worked on endocrine studies. Trust the data.

I don’t know OP clinical background so I won’t offer advice as I am a HCP & it wouldn’t be appropriate to do that - she’s not my patient. I could tell her what I do, which is 7mg every 10-12 days - but that’s what works for me. I’ve been maintaining on that dose for 7mth following a 24kg loss.

You can track all the calories you want. Fill up on as much protein as you can stomach. Long term it will not work. The clinical evidence is there and like a PP said, you’d have to be under a rock not to know it.

How much does that cost you per month?

Loubylie · 17/05/2025 17:06

@AgathaMystery And are you happy to stay on WLI forever? Do they not have any side effects for you?

puffinchuffin · 17/05/2025 18:06

Loubylie · 17/05/2025 17:06

@AgathaMystery And are you happy to stay on WLI forever? Do they not have any side effects for you?

speaking from my own experiences a year in, the side effects lessen over time, so whilst i got bad side effects as i moved up doses, they were temporary and eased off, now i have no side effects at all. Like with a lot of medications, it just takes your body time to adjust some times and sticking with it

AgathaMystery · 17/05/2025 18:18

Loubylie · 17/05/2025 17:06

@AgathaMystery And are you happy to stay on WLI forever? Do they not have any side effects for you?

I think I’ll be on some sort of GLP-1 forever, yes. I doubt it will be injections. I don’t have any side effects except Bruxism for 24-48 hrs after I titrate up a dose. I’m not titrating now so haven’t really struggled. I did have headaches about a year ago - that wasn’t nice.