I am one of those for whom this is a lifelong battle. Before MJ I worked out that I had lost several hundred lbs in my life - the same 20-50lbs over and over again, only to rebound.
I then took some time to read about the hormones that drive appetite, satiety, hunger and how gut health, UPFs affect them and how large weight loss (more than 10% body weight) affects them - and carries on affecting them long after the weight comes back. It's an uphill fight on a hill that gets steeper and steeper until you slip and crash back to the floor. Once I realised that, I realised that I probably had about the same chance of keeping weight off by myself as I had of winning the lottery. (And it would be better than a lottery win, imo).
MJ doesn't correct all of that. Cutting out UPFs and increasing gut health is on me. I am happy to do that. I cannot control leptin and ghrelin levels, but MJ can help with that. What IS an interesting question to me is 'to what degree are the hormonal feedback loops in weight loss negated by the fact that MJ is helping control leptin and ghrelin levels?'. i.e. without the 'normal' hormonal fluctuations that go with weight loss, does your body even 'know' you are losing weight and so, do the normal rules about starvation etc apply? I don't know the answer to that and have heard obesity scientists suggest not. But I don't know.
Anyway, for me this looks a lot like a long term deal. I have factored it into my budget on an ongoing basis and will keep with it. When I get to goal, I am minded to hold the dosage for at least 3-6 months while trying to eat a bit more to maintain. If that works, then drop down a dose for a few months and titrate down at a very slow pace to find the minimum viable dose for me. If that ends up being 0mg then that would be great. But if it doesn't and I have to take MJ for the foreseeable, then that is fine too.
Who knows what the future brings in terms of breakthroughs and further options? A friend was just invited to a trial for a pill version of ozempic (to protect against heart issues) so there are pills out there on their way...