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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

Side effects SOS

72 replies

Lolly2803 · 05/04/2025 19:08

Hi,
I lied to get mounjaro as I do have some weight to lose. Took my first dose on Thursday. Today I haven’t been able to leave my bed. Severe diorrhea, tummy cramps, had a rash on my forearms and I’ve got horrid burps. I’ve been on the loo all day. When will this end. I feel horrific. When will it end?

OP posts:
ILoveMJ · 06/04/2025 09:04

Lolly2803 · 06/04/2025 08:59

I know all these things and I feel awful. I think my bmi is 27. But you’re right it was vain, selfish and stupid and when feeling low I was sucked into all the hype of everyone taking it. But oh how I regret it. I’m trying with the water but it’s at the stage where can rinse my mouth out with water to get some moisture but not swallow. I’ve had constant diorrhea for 24 hours. I don’t know how much more there is. It’s just water!
I feel awful both physically and mentally. I was just looking for advice and to give a bit of warning to others that’s all. But the negative comments are deserved. 😓

OP, the negative comments are not deserved. Be kind to yourself. Some people can be so nasty and judgemental. There are thousands of people taking glp1's when they are not obese. Most people are fine. You have been unlucky, but don't beat yourself up too much.

Please go to the doctor though.

It could also just be that you coincidentally have a really bad stomach bug or something.. (unless you r having an allergic reaction (which you may be), the symptoms you describe sound v v unusual for a dose as low as 2.5mg)

Lolly2803 · 06/04/2025 09:10

I think part of it is an allergic reaction as I came out in a rash on both my forearms. Don’t think it’s a bug, it feels different. It’s debilitating and the stomach cramps feel different. I think I’m really dehydrated but hoping to get some meds in today that will allow me to sip some water. I have never felt so unwell (apart from when I have been seriously ill) I took the jab on Thursday morning. Had some milks nausea but did eat spicy brocoli and steak which maybe also hasn’t helped.

OP posts:
ILoveMJ · 06/04/2025 09:12

Lolly2803 · 06/04/2025 09:10

I think part of it is an allergic reaction as I came out in a rash on both my forearms. Don’t think it’s a bug, it feels different. It’s debilitating and the stomach cramps feel different. I think I’m really dehydrated but hoping to get some meds in today that will allow me to sip some water. I have never felt so unwell (apart from when I have been seriously ill) I took the jab on Thursday morning. Had some milks nausea but did eat spicy brocoli and steak which maybe also hasn’t helped.

💛🤒💐Hope you start to feel better soon.

Blodwyn831 · 06/04/2025 09:12

Lolly2803 · 06/04/2025 08:59

I know all these things and I feel awful. I think my bmi is 27. But you’re right it was vain, selfish and stupid and when feeling low I was sucked into all the hype of everyone taking it. But oh how I regret it. I’m trying with the water but it’s at the stage where can rinse my mouth out with water to get some moisture but not swallow. I’ve had constant diorrhea for 24 hours. I don’t know how much more there is. It’s just water!
I feel awful both physically and mentally. I was just looking for advice and to give a bit of warning to others that’s all. But the negative comments are deserved. 😓

They aren't. You're only human and deserve compassion when you're ill and at your lowest. No judgement from me. Life is hard. The pressure to be thin and lose weight is huge and as a previous poster said it's a complex issue. If it wasn't there wouldn't be so many of us desperate to try MJ. Really hope you start to feel better soon. Lucasade sport and bananas might help.

almostbloody50 · 06/04/2025 09:12

Lolly2803 · 06/04/2025 08:59

I know all these things and I feel awful. I think my bmi is 27. But you’re right it was vain, selfish and stupid and when feeling low I was sucked into all the hype of everyone taking it. But oh how I regret it. I’m trying with the water but it’s at the stage where can rinse my mouth out with water to get some moisture but not swallow. I’ve had constant diorrhea for 24 hours. I don’t know how much more there is. It’s just water!
I feel awful both physically and mentally. I was just looking for advice and to give a bit of warning to others that’s all. But the negative comments are deserved. 😓

The negative comments are just spiteful, I’m a 28/29 BMI and have always had a fairly good relationship with food, diet and my body but even I have considered “trying” I’m curious to see what food noise feels like when switched off, curious how my body would react and seems just far too easy.

If I took it I imagine myself looking all slim in my summer dresses size 10 instead of 12 swooshing around, not laying in bed vomiting up water.

Your post has helped many people like me to think you know what.. maybe not! Maybe I’ll even just get to the gym today.

I do hope you get better soon and thanks again for the reality check and helping others.

Pyjamatimenow · 06/04/2025 09:20

I’m not judging, my bmi was similar when I started on it. I’ve been on it a year. i’m still taking it and my bmi is 20. You’ve just been unlucky here. It will leave your system soon though. Probably tomorrow you’ll feel better but if you’re really worried do get seen

Blodwyn831 · 06/04/2025 16:06

Are you feeling any better OP?

Lolly2803 · 06/04/2025 18:16

Thank you for asking. I am feeling better. I’ve been able to keep little sips of water in. I feel dreadful but glad the cramping and constant flow of being on the loo has stopped. Haven’t eaten since yesterday morning and even though I can’t think of anything worse right now I’m too scared anything I do eat will bring on symptoms again.

OP posts:
Mysticmaiden · 06/04/2025 19:01

What's worrying is so many people replying saying they are not even obese and lying to get mounjaro. Come on, why do you need to do that? If I was a stone off normal weight I would've gone down the diet and exercise route not taken a systemic weight loss drug prescribed for obesity. I'm actually really surprised, didn't think there were so many.

ILoveMJ · 06/04/2025 19:16

Mysticmaiden · 06/04/2025 19:01

What's worrying is so many people replying saying they are not even obese and lying to get mounjaro. Come on, why do you need to do that? If I was a stone off normal weight I would've gone down the diet and exercise route not taken a systemic weight loss drug prescribed for obesity. I'm actually really surprised, didn't think there were so many.

Because we all know how easy the diet and exercise route is 🙄

(I've run a couple of marathons, countless half marathons, swim regularly, walk my dogs an hour every day. I've tried every diet going. Life isn't always as easy as 'just diet and exercise'!)

Mysticmaiden · 06/04/2025 20:07

ILoveMJ · 06/04/2025 19:16

Because we all know how easy the diet and exercise route is 🙄

(I've run a couple of marathons, countless half marathons, swim regularly, walk my dogs an hour every day. I've tried every diet going. Life isn't always as easy as 'just diet and exercise'!)

Edited

Not for genuine obese users or those with a health condition. I mean for those close to normal bmi with no metabolic condition that is lying to get the drug. I have insulin resistance and inflammatory conditions and a starting bmi of 32.4 and tried the diet and exercise route and lost 5lbs in 5 weeks, so it is possible just takes longer, but it didn't resolve my unstable blood sugar, which mounjaro has.

fedup1212 · 06/04/2025 20:11

Hope you feel better soon OP. It does sound a very extreme reaction. I know people who are on it with BMIs of 21 and they haven’t had such a reaction so I doubt your BMI is what caused the issue. It is deemed clinically appropriate with a BMI of 27 and a comorbidity.

Lolly2803 · 06/04/2025 20:41

Yer I think it’s just bad luck. I am hoping to wake up tomorrow feeling significantly better. I regret it totally but have well and truly learnt my lesson.

OP posts:
ILoveMJ · 07/04/2025 07:59

Feeling any better today?

Lolly2803 · 07/04/2025 08:14

Yes lots better today. Still really weak and a bit dodgy but much better. Can function. Not sure I will eat again today. The thought of food makes me feel sick. But maybe will try something tonight. See how it goes. Just had a decaf cup of tea.

OP posts:
ILoveMJ · 07/04/2025 09:29

Lolly2803 · 07/04/2025 08:14

Yes lots better today. Still really weak and a bit dodgy but much better. Can function. Not sure I will eat again today. The thought of food makes me feel sick. But maybe will try something tonight. See how it goes. Just had a decaf cup of tea.

Glad you r feeling better. Hope you can eat soon. As my mum would have said 'try and keep your strength up' (not sure how you are meant to do that! But she used to ply me with lucosade and try and encourage me to eat dry toast! So...) x 💐

Lolly2803 · 07/04/2025 09:33

Yer I’ll brave something later but right now the thought of chewing and swallowing is a no! Would love a coffee though! Perhaps decaf will be ok?

OP posts:
ILoveMJ · 07/04/2025 09:47

Mysticmaiden · 06/04/2025 20:07

Not for genuine obese users or those with a health condition. I mean for those close to normal bmi with no metabolic condition that is lying to get the drug. I have insulin resistance and inflammatory conditions and a starting bmi of 32.4 and tried the diet and exercise route and lost 5lbs in 5 weeks, so it is possible just takes longer, but it didn't resolve my unstable blood sugar, which mounjaro has.

Edited

What on earth makes you think a 'genuine obese user' finds exercise and diet harder than me or anyone else? Unless you have medically tested and rigourously established everybody's food noise, hunger levels, activity, metabolism, hormones, reactions to advertising, smell and taste senses etc.. etc.. etc.. then you simply don't know what you r talking about.

A lot of people struggle enormously with losing weight and keeping it off with diet and exercise alone. I have been on what feels like every diet that has ever existed, starting at age 8. I'm now 47. I have over-exercised including running to and from work, using the work gym in the morning before work after my first run, and running again in the evening when I was in my twenties (that's 3 runs and a gym session every single day), just to stop myself becoming overweight. I have tried fasting (starving myself basically, let's call it what it is), purging, Atkins, the orange and coffee diet, low carb, low calorie, vegan, vegetarian, clean eating, everything. For years and years and years I have battled constant food noise and hunger and thoughts about calories. I know the calorie in absolutely any food you could name. I'm exhausted.

When I started mounjaro I was around BMI 27. I am now in the healthy weight range. Mounjaro has changed my life. I can exercise at sensible levels and eat healthily without the internal mental struggles, food noise and everything else. I don't have to kill myself with two or three workouts a day just to stay at a healthy BMI. I feel normal. I feel like moderation is nice. I feel rejuvenated and happy.

I like how I look. I like that I am no longer mentally and physically exhausted with trying to loose weight. I am happy. I don't have to track my calories all day every day. I can just relax and enjoy life.

A LOT of people struggle with weight. You cannot tell simply by looking at someone or seeing their BMI what they are going through. We should all support each other.

You seem to think dropping 5lbs is easy. You say you've done it in 5 weeks! That's great. Why didn't you do it again, and again, and again til you lost the weight you needed to? ... because it's not that easy is it. We all know that. We know it's harder than it sounds, especially to keep it off. Instead of expecting others to do what you cannot do because you think they are somehow biologically more able than you, perhaps try being more supportive and recognise that maybe other people share your struggles. Just because someone else doesn't have the same weight or medical difficulties as you, doesn't mean everything comes easier for them.

ILoveMJ · 07/04/2025 09:47

Lolly2803 · 07/04/2025 09:33

Yer I’ll brave something later but right now the thought of chewing and swallowing is a no! Would love a coffee though! Perhaps decaf will be ok?

Yeah! Small sips :) good luck 🤞 🤞

Herewegoagainandagainandagain · 07/04/2025 10:38

ILoveMJ · 06/04/2025 05:05

I'm sorry you're feeling awful.OP :(

I inflated my weight a bit on the online forms to get mj. Plenty of people have done so, and plenty more will continue to do so, so don't beat yourself up too much! Sharon Osbourne and multiple other celebs have taken GLP1s when they were clearly not obese. You r not alone.

I doubt very much that your BMI has anything to do with your reaction.

I took mj with a BMI just under 27 and I've been absolutely fine. A bit tired but that's all. I've had no nausea or diarrhea or anything. I've lost 3 stone and very happy with the experience of taking mj.

I wonder if you r having an allergic reaction.

Go to the GP. They will.understamd.

I know people can be very critical when people are not honest in order to obtain a prescription, but thankfully I expect GPs will understand. They know how much weight effects us and that when people r desperate to loose weight they will b tempted to try glp1's. I don't regret taking it. It's changed my life. You weren't to know what reaction your own body would have.

Good luck. Hope you feel better soon.

Sharon Osborne has had medical interventions through her life for obesity including a gastric bypass and has been over 100lbs overweight before. She obviously struggles with obesity and has been prescribed based on this with support from private doctors. It is not comparable to someone who has never been obese.

Many GP's barely understand or support severely obese patients taking it privately, it is even more unlikely they will understand or be supportive of someone lying to obtain it outside of the prescription guidelines.

There are risks associated with these medications which is why there are prescription guidelines where they have balanced the risks vs the benefits to resolving obesity. The risks of the medication are considered by the manufacturers and medical professionals to be too high for cosmetic weightloss. Glad you have not had any serious side effects, but your reckless actions would not be condoned by any medical professional.

ILoveMJ · 07/04/2025 10:48

Herewegoagainandagainandagain · 07/04/2025 10:38

Sharon Osborne has had medical interventions through her life for obesity including a gastric bypass and has been over 100lbs overweight before. She obviously struggles with obesity and has been prescribed based on this with support from private doctors. It is not comparable to someone who has never been obese.

Many GP's barely understand or support severely obese patients taking it privately, it is even more unlikely they will understand or be supportive of someone lying to obtain it outside of the prescription guidelines.

There are risks associated with these medications which is why there are prescription guidelines where they have balanced the risks vs the benefits to resolving obesity. The risks of the medication are considered by the manufacturers and medical professionals to be too high for cosmetic weightloss. Glad you have not had any serious side effects, but your reckless actions would not be condoned by any medical professional.

I didn't say a GP would condone the actions. I said they would understand. Because most GPs understand life isn't black or white. Most have empathy and compassion. Most realise people are human and fallible and imperfect and sometimes need advice. Most realise that judging without knowing the facts is not helpful. Most GPs would want to understand why someone was so desperate and unable to loose weight any other way, that they resorted to a GLP1. Most GPs are decent people that want to help.

ILoveMJ · 07/04/2025 11:03

Herewegoagainandagainandagain · 07/04/2025 10:38

Sharon Osborne has had medical interventions through her life for obesity including a gastric bypass and has been over 100lbs overweight before. She obviously struggles with obesity and has been prescribed based on this with support from private doctors. It is not comparable to someone who has never been obese.

Many GP's barely understand or support severely obese patients taking it privately, it is even more unlikely they will understand or be supportive of someone lying to obtain it outside of the prescription guidelines.

There are risks associated with these medications which is why there are prescription guidelines where they have balanced the risks vs the benefits to resolving obesity. The risks of the medication are considered by the manufacturers and medical professionals to be too high for cosmetic weightloss. Glad you have not had any serious side effects, but your reckless actions would not be condoned by any medical professional.

Why do you assume my actions were reckless? My actions were not reckless, but rather very well considered. I am very well aware of my body, my struggles with weight and how I feel. I also read pretty much every research paper on GLP1s that I could get my hands on. My considered opinion, after doing my research, was that GLP1s were unlikely to do me anymore harm and were unlikely to be any riskier for me than for someone heavier with more medical problems. Most research points to them being pretty safe with only mild effects for most people and serious side effects being rare. I weighed up the costs and benefits to myself and made the decision to try mounjaro. A decision I do not in any way regret and which has been one of the best decisions I have ever made.

People may well disagree with my decision, but it wasn't reckless. It was quite sensible and very well considered. It may not be the right decision for other people. But it was right for me. It was morally wrong of me to lie to get it, but there was no way to obtain it honestly. And given how life changing it's been for me and that I strive in all other ways to be a decent human, I don't regret that lie and I am well aware that I'm not the only one inflating their weight by a few kgs to get a life changing medication. It would be fool hardy of regulators or anyone else to assume otherwise.

Herewegoagainandagainandagain · 07/04/2025 11:30

Regardless of the "research" you feel you have done or your medical self diagnosis it does not replace profession medical prescribing guidelines - borne from rigorous, controlled clinical trials carried out by qualified experts - which are there for very good reasons to protect from known and unknown harm.

Even if you feel ok now the facts are the risks of the long term effects of these drugs both physiologically and psychologically you don't know. That unpredictability with little knowledge of both areas as there have been no trials or research papers for you to read into them what you want to hear, makes your decision, based on very biased "consideration", reckless.

The difference you seem to ignore is obesity is a greater health risk than the potential of known and unknown harm from these drugs.

But of course the NHS is there to pick up the pieces for you if all goes wrong.

ILoveMJ · 07/04/2025 11:54

Herewegoagainandagainandagain · 07/04/2025 11:30

Regardless of the "research" you feel you have done or your medical self diagnosis it does not replace profession medical prescribing guidelines - borne from rigorous, controlled clinical trials carried out by qualified experts - which are there for very good reasons to protect from known and unknown harm.

Even if you feel ok now the facts are the risks of the long term effects of these drugs both physiologically and psychologically you don't know. That unpredictability with little knowledge of both areas as there have been no trials or research papers for you to read into them what you want to hear, makes your decision, based on very biased "consideration", reckless.

The difference you seem to ignore is obesity is a greater health risk than the potential of known and unknown harm from these drugs.

But of course the NHS is there to pick up the pieces for you if all goes wrong.

🙄

I pay my taxes which support everybody.

I understand some people are overweight and my taxes pay for the health implications of that. Some people are smokers and my taxes pay for the health implications of that. Some people are addicted to drugs and my taxes pay for the health implications of that. Some people engage in adrenaline sports and my taxes pay for the implications of that. Some people run ultramarathons and my taxes pay for the health implications of that. Some people send their kids on ski trips and my taxes pay for what may be the implications of that! Some people drive poorly and my taxes pay for the health implications of that. Some people engage in hoarding behaviour and my taxes pay for the health implications of that. Some people are in abusive relationships and my taxes pay for the implications of that....

Not everyone who ski's will break a leg. Not everyone that smokes will get lung cancer. Not everyone that overeats will get heart problem or diabetes. Not everyone that runs an ultra marathon will pop a calf muscle or suffer dehydration requiring a&e. However, the risk is there. They are making choices which could result in the tax payer footing the bill and the NHS being strained. But as we know, these 'choices' are not straightforward. When we 'choose' to eat that extra chocolate bar it's not really a free choice - it's driven by so many external, internal and biological factors. Equally, running an ultramarathon or engaging in adrenaline sports or smoking or taking drugs are all influenced by so many things. Life isn't about 'good humans' making sensible choices to eat well, exercise, do safe activities and live as a nun and 'bad humans' who purposefully make unwise choices and cause others to foot the bill. Life is complex and our choices not as free as we think. Noone really ever intends to cause harm by a choice they make.

I am happy to support others with my taxes because I realise that being overweight, smoking, taking drugs, driving too fast, doing adrenaline sports, running ultramarathons, being in a domestic violence relationship, hoarding and just 'life' things we do etc.. etc.. are complex. To be fair, my choice to take mounjaro is far less risky than if I was to start smoking, using heroin, cliff jumping, living with an abusive partner or doing any manners of other risky things. So far all it's done for me is to massively improve my mental health and reduce my risk of some health complications which come from being overweight!! So I am saving the tax payer and the NHS so far...

The NHS is for everyone. A lot of people under the NHS are there because of their own actions (smoking, drinking, over eating, adrenaline sports, being in a stressful job...). That's exactly what it's for. It's for us, fallible, humans whose 'choices' are, thankfully and beautifully, far far more complex than they may appear.

Herewegoagainandagainandagain · 07/04/2025 12:03

Yes the NHS is there for all and hopefully will remain there for a long time to come. It doesn't change the undeniable fact that your actions to obtain prescription only medication, illegally bypassing the protections in place, are reckless. 🤷‍♀️

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