Horrific side effects these last 2 weeks after months of nothing

[Eminybob]

I’ve been on MJ for coming up to a year. I am at target but still on 15mg and am planning to start titrating down soon.

I have been relatively lucky with side effects, with just a couple of weeks of sickness when I was on 7.5mg (I think). Otherwise apart from mild nausea and a bit of tiredness all good.

But these last 2 weeks, oh my god. The day or so after the injection I have been absolutely sick as a dog. Stomach pain, diarrhoea, vomiting, plus fatigue etc. I thought last week was a one off but I’m the same again tonight. I don’t think anything else has changed, I’ve not eaten anything out of the ordinary.

Any idea why I’m suddenly like this? Could it be more than just side effects? (Gallstones?) Will titrating to 7.5mg help?

And in the mean time any advice to help me feel better?

I have been very similar over the past two weeks. Minimal side effects since starting in October, lost over 20 kilos very easily with only mild constipation. Two weeks ago, 6 days after my first injection of 12.5mg, I spent 24 hours with abdominal cramps, diarrhoea, and huge amounts of vomiting undigested food. Left a two week gap between injections and reduced my dose back to 10mg, but still nauseous and sulphur burps. Have postponed my next injection and will reduce to 7.5mg.
My theory is that my reduced body mass is struggling to cope with the larger doses now. I’m almost at goal and a healthy BMI, so I’m probably going to titrate down to my own version of maintenance for the next few months.
I hope you feel better soon.

It could be food related, I started October on 10mg, only twice had stomach pain, diarrhoea both after eating fatty processed meat, meatballs and a greasy beef burger eugh never again. I read someone takes half doses twice a week which is more stable. I'm struggling to eat on 10mg first 3 days

Surely it is because you’re at target and do not need it??? Not listening to your body got you into this situation… why aren’t you listening now?

Got me into what situation exactly?

Are you sure it's connected and you don't just have a bug?

Well I thought that last week, but then it happened again this week so pretty sure it’s the MJ.

It could honestly be a bug, they’re talking in Ireland about a really bad stomach bug going around, dh was sick for more than one week with it. Now they’re telling people to try to stay away from hospitals with it and deal with gp instead

I would have thought that it is what another poster said. You have reduced your body mass significantly and the higher doses are too strong
You may need to start titrating down

I don’t know why people are surprised this drug is making them ill tbh.

That’s the plan now. I’ve been putting it off as honestly felt fine on 15mg and have been maintaining nicely. This is my sign it’s time.

Rather a couple of days of being sick than a lifetime of heart problems, joint problems and diabetes.

Yup.

Because you’re going up to super high doses when you’re not even obese anymore. So yes you are going to get side effects and yes they are side effects from the medication, not a bug. I was listening to a podcast by a US doctor the other day and he was like absolutely do not increase the dose unless you really feel it is doing nothing. Yet people blithely listen to a pharmaceutical company who has a vested interest in you paying more for the stronger product and then they end up in hospital or vomiting for days. I think people believe it’s not working if they feel even the slightest hunger - they’re eating 900 calories a day and then start saying “ooh the food noise is coming back, need to go up to the 12.5”. No, you need to eat an actual meal, that is hunger you’re feeling because you have been starving yourself for weeks. I’m not exaggerating- on the what I eat on Mounjaro thread there are so many people eating two minuscule meals a day, barely hitting 1000 calories and convinced it’s not working for them if they “only” lost two pounds that week.

I’m exactly the same as the OP, apart from same reaction at 10mg after 7 months in 2 consecutive weeks. I’m nowhere near goal and still BMI 29 with 2 more stones to go. It’s not a bug as it’s exactly 48 hours after jab both weeks and have horrendous diarrhoea . It’s a new pen and I’d almost swear it’s that as I’ve been fine on the other one. I’m going to have to go back down to 7.5 . Shame as I’ve been ok these last 7 months not many side affects and slow and steady. Some pointless and ,uneducated replies on here, ignore the catty remarks OP .

I've seen people report similar a few times now, OP, and the explanations offered so far on this thread don't seem valid.

Mounjaro isn't dosed based on body weight, and the SURMOUNT-4 trial went up to maximum tolerated dose and then kept participants there for a further year. During that follow-on year, 1.8% stopped due to adverse events compared to 0.9% of those on placebo.

https://pubmed.ncbi.nlm.nih.gov/38078870/

I'm sorry, it must be so disappointing to have such an awful reaction so far in.

I suppose I see it as being a bit like bad weather - sometimes it just happens, it certainly has for me. It will probably settle down. Not very sophisticated am I.

Remember as well that the half life is 5 days so every time you take it, there is more in your system than last time. So you may have been fine for 3 weeks on that dose but now it has tipped you over whatever your body’s limit is.
To be honest, I don’t think they have done enough studies to be able to completely conclude that BMI has zero to do with the impact. But when people of normal weight start taking it they often react very badly (and these are many of the cases where they end up in hospital) and people then explain it that they didn’t need it in the first place. But if it has nothing to do with current body weight then I’d expect a healthy weight person to be fine on it (it just delays gastric emptying).
I do think that in 5-10 years with more studies on this they will be telling people to start on lower doses and to stay low.

So much resistance to thinking beyond of weightloss here it seems….

Long term organ damage…The fact that these companies are making millions out of vulnerable people…. what happens when you stop taking the drugs…?

Seems like a lot of legal cases waiting to happen. Anyone mentioning this is dismissed as being negative or mean. Where has common sense gone? 🤷🏻‍♀️

The GLP-1 Receptor Agonist level only increases each week for the first three to four weeks of any dose increase, @Finallydoingit24. After that it reaches a steady state.

That’s interesting although on my Shotsy app it shows the amount increasing each week, not staying steady. Does the half life reduce then after 4 weeks?

I suspect that what a lot of people think is a side effect of the injections is actually the same as what’s called dumping syndrome in the world of bariatric surgery. It’s what’s being eaten that’s causing it. Not the injection or the surgery.

People always blame “what’s being eaten” when someone complains of horrible side effects on weight loss drugs, without any knowledge at all about what the OP has eaten.

I had to give up Ozempic due to horrible side effects and know I ate as recommended by the manufacturers but if I mention my side effects someone always suggests I ate too much fatty food or something.

Some people don’t suffer negative side effects on these injections & some people do, that’s a fact and even acknowledged by the manufacturers. It’s not a bug or a sign of eating the wrong things in most cases.

No, @Finallydoingit24, the half-life stays the same. It’s just an estimate of how long it takes for half of any drug dose to be cleared from your body.

Half of the initial dose of Mounjaro is left in your body after five days, and that half decreases by 50% again after another five days. So the level in your body only accumulates until the first dose is cleared out of your system.

I’m not sure what Shotsky is showing.

People always blame “what’s being eaten

Always?

Im sorry but that generalisation alone says all there is to say about your post.

What I mean is on any MN thread about someone on weight loss drugs suffering bad side effects someone will suggest they ate something unhealthy. Even in this case where the OP has been on the medication for coming up to a year, hasn’t eaten anny out of the ordinary and is only now suffering bad side effects.