Weight loss injection cancer risks

[Holyguacbatman]

Hi
I have been doing some research and hoping someone can do help point in the right direction. I have massively overweight and have bad health anxiety. I really want to start on the injections but am worried about thyroid cancer. Does anyone have any links to medical research rather than just online articles?

I know being overweight probably holds more cancer risk but want to see that in writing to ease my mind.

Thanks

I'm not an expert but under no circumstances would I risk weight loss jabs. They are too new. I would want to see a lot of careful research after a decade or two. (I do realise that means other people would have to take them 😅)

At a high level the link with thyroid cancer was seen in a small study with mice and never replicated in human studies. It's worth also considering that cancer is not a simple disease and what may increase the chance of one type may decrease the chance of another - it's almost always a pay off between the two. Obesity is a risk factor for many types of cancer in itself.

However, if you want to read through the a study discussing WLD and cancer: https://pmc.ncbi.nlm.nih.gov/articles/PMC9687454/

and

https://www.e-enm.org/journal/view.php?number=2572

more worried about blindness tbh

The thing about linking to specific papers about one topic or another, is the risk of cherry picking and of not understanding the research context.

If you consider the MHRA in the UK has approved both semaglutide (Wegovy/Ozempic) and tirzepatide (Mounjaro) for use for weight loss, as well as for diabetes. The NHS has therefore also decided to roll it out to obese people starting with the most obese with weight related health conditions starting in the summer. Similar is true in countries like the US, Australia, Ireland etc. This would not be the case if there was a proven risk of increased thyroid cancer for people taking these medications.

The risk of thyroid cancer in humans has not been shown to be increased by the use of GLP1s like Mounjaro and Wegovy. The risks of many different types of cancers from being obese are well known. If you take a GLP1 and lose a significant amount of weight, you will be reducing your overall risk of getting cancer.

@IronDoll there is no issue with "blindness". There was a recent piece of research which looked at US ex-army members who had been taking semaglutide, this BBC article gives a fair summary https://www.bbc.co.uk/news/articles/c80ew38gkdxo

An important point from that article - "But the researchers cannot prove semaglutide caused the eye condition, which can lead to loss of vision in one eye, nor can they explain the increased risk or the difference between the groups. The numbers affected were small."

Across the 17,000 people they looked at, a total of 46 people developed the eye condition NAION, 9 were not taking semaglutide and 37 were. Many were taking it for diabetes, which itself is a risk for NAION, as is losing weight in general. So not possible to say atm whether semaglutide actually increases the risk, or if this is correlation rather than causation.

What an odd response to a thread on the WLI board! Good news though, people have been using WLI for decades already so all of that information is out there if you did want to look for it.

The cancer risk from obesity is substantial. Cancer Research say that 1 in 20 cases of cancer are caused by obesity. Losing weight reduces the risk of many types of cancer. The increased risk of thyroid cancer from WLI (if there is one) would have to be pretty huge to outweigh the cancer risks of obesity.

https://www.cancerresearchuk.org/about-cancer/causes-of-cancer/bodyweight-and-cancer/how-does-obesity-cause-cancer

After a decade or two? Would 18 years of use in diabetes suffice? All the clinical trials that have been going on for years too? 🙄

They are not new!

Safe to say you didn’t take the COVID jab then ….:::

We have research from a decade or 2 already

2022 is pretty new.

2022 is pretty new.

But Mounjaro has been around a lot longer than that?

I wrote almost exactly the same as you a while ago, still too anxious to do it. Following your post. Health Anxiety is the worst.

2022 for Diabetes. How long has it been around?

I'm more worried about the proven risk of blindness from diabetes that I'm more likely to develop if I continue to be obese much longer.

@Hotpinkangel19

2022 for Diabetes. How long has it been around?

That's when it was approved: not how long it's been around. Nothing gets approved without years of testing.

Happy to be a Guineapig for a drug that's perfectly well tested, safe enough to be prescribed by a pharmacist and has already significantly reduced my chances of developing obesity related diseases. Two more decades of increasing my BMI and goodness knows what state my health would be in. Down from 35 to under 30 in 4 months. Mounjaro may have given me an extra decade of healthy life if I continue on this path.

Thank you that's all really helpful.

I know rationally that the weight I am is much more of a health risk especially as I hold a lot of weight on my stomach. It is not a good situation but in my head I feel like it isn't good but also isn't something unnatural but once I take a drug then I can't go back and undone that. I don't even know if that makes sense!

Anyway I am going to face my fears and give it a try. So next question is how do I chose a prescriber and a drug?

Thanks

If you go to monj.co.uk it has prices for providers both before and after discounts. Only proper suppliers are listed on there. It also has support package info. Take a look and pick the one that feels best to you. You can always change. I've gone with Ashcroft for their quick delivery, provision of needles, wipes and sharp box and transparent pricing but there's lots of options.

You do know they are twenty years old?

Which weight loss drug was first introduced in 2022?

I've been through various suppliers trying to get the best price since march next year.

This year my mum and sister have been using shemed. And I think it's brilliant and wish it had been around when I started. They give real support, phone calls every week and recommendations based on how you're responding. They even supply extra medication for side effects.

After seeing the support they are getting I would recommend shemed to anyone.

I would say if you are truly concerned about cancer - reducing sugars is simply the best thing you can do..

my friends who both had cancer first thing they did was cut sugars.

i say this as someone who did Weygovy so not against it at all. ..