Messed up the maths with Mounjaro

[coffidu]

I have just finished my second 7.5 pen. The first gave me bad nausea and some vomiting for 48 hours for the first two doses, so I decided to increase to ten gradually on the second pen. Except, I did the maths wrong and have just taken my third dose of 11.25. I used an insulin syringe and took .9 (a full dose is .6) so not the 8.75 I'd intended.

I'll be starting my 10mg pen next week, so want to take one more dose at 11.25 before moving up to 12.5. Can someone please, please tell me how to get this out of a 10 pen first of all? And then, am I right in thinking 15 clicks on top of the full dose will give me 12.5?

Luckily, I've had no side effects from this stupid error, but I feel such an idiot 😞

I hope you feel ok and that you will be alright.

I can't for the life of me understand why people are fucking about with this medication so much.

@RoastLambs As I said I've been fine for a couple of weeks, no side effects at all. Thanks for the helpful comment 🙄

🙄

You are so very welcome.

Why are you jumping from 7.5 to 12.5 using a 10mg pen? Shouldn't you be on 10mg for a month before moving upto 12.5mg? It's a huge jump

@Mysticmaiden2024 did you read my op in full?

I read it in full and cannot for the life of me figure out what you are trying to do - or why. Except that it seems to be against the guidelines.

Why not just follow the manufacturer's recommended titration schedule?

It would be simpler just to take 4 doses of 10mg, as you originally wanted to go to 10mg before mistakenly taking 11.25. Why rush up to 12.5? I don't understand the motivation to do that.

Totally agree

Hey, no judgement from me, ive been on mounjaro myself. All i will say is its a lesson learnt hopefully and think logically when applying for prescribed medication there are licenced doctors who look at your needs in regards to dosage by referring to the statistics gathered from trials so its important to trust in the research rather than being too blindsided by deciding alterior dosage amounts off of symptoms. Your GP will be given a record of medication if approved by ypu so speak with a gp or one of the doctors through your provider before making adjustments.

Yes I read it 3 times and couldn't understand what you are doing and why. You haven't mentioned being on 10mg at all, just that you had a 7.5mg pen wanted to take 8.75mg but accidentally took 11.25?? Now wanting to take 12.5mg. This is baffling and not recommended at all. FYI I'm a registered health professional. Please contact your provider but I would recommend going up in the staggered doses published

Dose in clicks = (desired dose/standard dose) x 60

Dose in ml = (desired dose/standard dose) x 0.6

So to get 11.25 mg out of a 10 mg pen = 11.25/10 x 0.6 = 0.675 ml = 0.68 ml

You're moving up the doses very quickly considering you had nausea and vomiting when you first went up to 7.5 mg. Are you getting very little/no suppression now?

Have you done (are planning) this:

Pen 1 (2.5 mg) - 2.5, 2.5, 2.5, 2.5
Pen 2 (5.0 mg) - 5.0, 5.0, 5.0, 5.0
Pen 3 (7.5 mg) - 7.5, 7.5, 7.5, 7.5
Pen 4 (7.5 mg) - 7.5, 7.5, 11.25*, (11.25)
Pen 5 (10.0 mg) - (11.25)

Bolded - bad side effects
underline* - mistake dose that luckily worked out ok
(brackets) - future planned doses

Just read your OP again - think it might be this?

Pen 1 (2.5 mg) - 2.5, 2.5, 2.5, 2.5
Pen 2 (5.0 mg) - 5.0, 5.0, 5.0, 5.0
Pen 3 (7.5 mg) - 7.5, 7.5, 7.5, 7.5
Pen 4 (7.5 mg) - 7.5, 11.25, 11.25, 11.25*
Pen 5 (10.0 mg) - (11.25)

Bolded - bad side effects
underline* - mistake dose that luckily worked out ok
(brackets) - future planned doses

cp. to standard (fastest possible) recommended dosing schedule:

Pen 1 (2.5 mg) - 2.5, 2.5, 2.5, 2.5
Pen 2 (5.0 mg) - 5.0, 5.0, 5.0, 5.0
Pen 3 (7.5 mg) - 7.5, 7.5, 7.5, 7.5
Pen 4 (10.0 mg) - 10.0. 10.0, 10.0, 10.0
Pen 5 (12.5 mg) - (12.5)

Did you use an insulin syringe to extract the medicine from the pre-filled pen before injecting it into yourself? This is truly daft and risky. Medicines are not things you play with.

I also don’t understand why you want to move straight to the 12.5 and ski the 10. Okay so you took a bit of an overdose but you were okay so don’t keep taking that - go back to 10.

@Shatandfattered yes, lesson learnt. And thanks for not being judgemental.

@SubDoser thanks for the calculation.

This is what I've done since October. As you can see, I haven't moved up as quickly as some people who have followed the moving up a pen each time advice.

Pen 1 2.5mg, 5 doses (used the bonus dose) nausea and vomiting overnight for 12hrs after first dose
Pen 2 5mg, 5 doses, nausea for first 24 hours after first dose
Pen 3 5 mg, 5 doses, no side effects
Pen 4 7.5mg, 5 doses, nausea and one bout of vomiting in 12 hours after first injection
Pen 5 7.5mg, dose 1 normal 60 clicks of pen, no side effects. Dose 2 wanted to increase to 8.75 but got it wrong and injected 11.25. Absolutely no side effects whatsoever. Have done a further two doses of 11.25 with no side effects. I now want to do another week, possibly two, at 11.25 before moving up to 12 and injecting as prescribed. Suppression is wearing off by day 5 but able to make good food choices on the days of less suppression.

Thanks for clarifying @coffidu . Makes complete sense what you were trying to do and why - glad the slip with the dose turned out to a better dose for you in the end.

Thanks @SubDoser.

Just take the 7.5

I don’t understand why you are fucking about with it so much.

I think the problem with doing all this is that you have missed out experiencing/learning what many people experience - that when you get to month 4 or so, you tend not to get the nausea with increased doses anyway, because your body has adjusted overall to the medication.

This is why so, so many people are amazed to discover that they have fewer side effects on 10mg than on 7.5mg for example.

It isn't the gradual dose increase that is helping mitigate side effects. It is the total time taking the drug as well.

@Zempy I've gone into detail in my last but one post. Why would I move back down to 7.5 when I'm tolerating 11.25 extremely well? It would also mean fucking around with the dosage again as I don't have a 7.5 pen now.

Because pretty soon you'll at maximum dose and I know several people who have said after 2/3 weeks on Mac the suppression is waining.

It's best not to get there at all if you can avoid it or at least delay it.

I never went above 7.5 and then stopped at target.

Because it’s sensible to take the minimum dose that is effective rather than chasing very high suppression by going for higher doses. but each to their own.

On max. Not Mac.

I still think the simplest thing to do is to just take the 10mg pen for 4 doses using the pen as intended. Rather than try to get 12.5mg doses out of it and risk another error. Then either stay on 10mg or move up to 12.5mg if the 10mg is no longer effective.

I'd assume suppliers wouldn't let you just skip ahead despite messing up the doses.