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Weight loss injections/treatments

Discuss weight-loss injections and treatments, including personal experiences. Mumsnet hasn't checked the qualifications of anyone posting here. You may wish to speak to a medical professional before starting any treatments.

When did your loss start to slow down?

27 replies

Heydiddlediddlethe · 13/02/2025 16:42

i started at 86 the end of dec and i’m now 77 and not lost much in the last 2 weeks but my suppression i feel is still good and don’t eat much.
i have the 5mg mounjaro but so far only used 40 clicks as didn’t want to go up too quickly plus i feel i’m still able to eat little.
Im not near my optimum weight so not really sure as to why the loss slowed down?

OP posts:
Goinghome2 · 13/02/2025 17:18

Mine slowed right down after the first 4 weeks. I have had 2 weeks where I lost nothing at all.

Still avereges out at 2.2lbs a week over the 10 weeks I have completed.

Healthy weight loss.

Gettingslimmer · 13/02/2025 17:26

If it slows down it is due to eating too many cals. The drugs don’t make you physically lose weight, what you don’t eat does.

MaybeMrs · 13/02/2025 17:28

I slowed right down on 5mgs. Now I’m on 7.5 it has gone up again and I’ve lost 4lbs in my first week. I’m in week 9 and lost 31lbs.

IHateMozzies · 14/02/2025 09:50

Week 2!

85reasons · 14/02/2025 10:06

@Gettingslimmer It's not as simple as that. My weight loss slowed down/stopped after a couple of months and at some points I was struggling to get to 1000 cals a day. My prescriber advised me to increase my calories - too low an amount and the body clings on to the fat thinking a famine is coming. I think it's easy on MJ to slide into eating less and less, especially as a slowdown in weight loss incentivises people to move up to higher doses. Appetite suppression increases and you eat less - but the weight continues to stay static.

Lots of people are experiencing this OP - you can try calorie cycling (having a couple of days of increased calories throughout the week) to stimulate the body to let go of weight - have a google as there's lots of information about how to do this.

Finallydoingit24 · 14/02/2025 10:57

Gettingslimmer · 13/02/2025 17:26

If it slows down it is due to eating too many cals. The drugs don’t make you physically lose weight, what you don’t eat does.

Not how it works. If it was, chronic undereaters would lose weight until they disappear and we know that’s not the case. Your body adapts and weight loss slows or stops. For example, with bariatric surgery, the weight loss will stop eventually even if the patient can only eat small portions due to their smaller stomach. Normally you will only lose so much of your starting weight and with Mounjaro it tends to be around 20% according to the clinical trials.

Heydiddlediddlethe · 14/02/2025 17:19

Thanks both @85reasons and @Finallydoingit24 this is what i thought. As i said my suppression is still good and only eating a couple of small meals so it’s not that im not in calorie deficit. I will try the upping the calorie a bit but have to be careful as it makes me feel quite queasy eating more.
Thanks again. Will let you know how it goes

OP posts:
newyearnewme2025 · 14/02/2025 17:33

i never had massive loses from the start. its was always 1 or 2 pounds, and i was very happy with that. i ensured i followed a calorie deficit and tried to eat properly, the biggest help for me was just the removal of food noise. for the first time in forever i didn't spend my entire waking hours thinking about food.

LindtCurves · 14/02/2025 18:00

I am almost to the dot in the same place as you. Same starting weight, now stuck, same dose.

I lost about 10% of my body weight very quickly, 2 months. Now stuck for about 6 weeks.

I am eating little, good foods, suppression is good. Perhaps I could be a bit more active.

What I’m thinking of doing is, I probably eat too little. So the idea now is to up exercise and up what I’m eating too, and see what that does. I’ve ordered a 7.5mg pen too.

I think this 76-77kg is my new set point and it’ll take more effort to push past that.

Choux · 14/02/2025 18:57

My weight loss was pretty constant over the 9 months I was losing weight. A few increases from holidays and even a meal out with carbs and alcohol could give me a week of no loss but then a high loss week the following week when I got back to a good diet. I did go up to 15mg though as I am not a super responder.

Over the 9 months I lost on average about 1.3lbs a week to lose 26% of my starting weight. Currently maintaining on 10mg and hoping to go down to 7.5mg in a couple of months.

When did your loss start to slow down?
HowardTJMoon · 14/02/2025 19:55

wrong thread

Gettingslimmer · 14/02/2025 20:22

Finallydoingit24 · 14/02/2025 10:57

Not how it works. If it was, chronic undereaters would lose weight until they disappear and we know that’s not the case. Your body adapts and weight loss slows or stops. For example, with bariatric surgery, the weight loss will stop eventually even if the patient can only eat small portions due to their smaller stomach. Normally you will only lose so much of your starting weight and with Mounjaro it tends to be around 20% according to the clinical trials.

Um that is how it works, well they don’t disappear, but if they don’t regain then it is fatal, why do you think anorexia is fatal for some. Why they become skeletal. You cannot seriously think they just find a set point and stay there. Surely not?

and I’m already at 25 percent.

Confused
GoldfinchesInTheTree · 14/02/2025 21:32

I really need to lose more than 20%. I hope mine doesn't stop there as I'd still be morbidly obese. Very.

SilenceInside · 14/02/2025 21:43

The recent SURMOUNT-4 clinical trial showed an average weight loss of 25.3% over 88 weeks. As it's an average, individual results will vary. I have been on Mounjaro for 32 weeks and have lost 32% of my starting weight. I have another 4 stone to lose, and will hopefully end up losing over 50% of my starting weight.

unsync · 14/02/2025 22:12

I've lost 26.4% since 31 March 2024 - 31.3 kg. Current rate is .7 kg per week. Slow and steady. I calorie count and exercise consistently including weight training four times a week. You shouldn't be losing more than 2 lbs a week as that's not supposed to be healthy or sustainable. What's your TDEE and deficit?

Swalwey · 14/02/2025 23:47

9 kilos in six weeks is very good.

If you want to keep losing weight steadily, why not follow the regular treatment plan and move up dosage every month as you’re supposed to do? I see so many posts where people are disappointed with their loss but are staying at a lower dose than they should. Unless your side effects are unbearable, I would adjust your dosage upwards as a first step.

GoldfinchesInTheTree · 15/02/2025 04:15

I'm not sure you're "supposed" to move up every month? All the advice I've seen suggests you stay at the lowest you can with weight loss as once you're at the top there's "nowwhere to go", other than the 2.5 dose which is just a springboard Rd to 5?

Ie if you're losing on 5 you stay on 5 until you're not?

Inwonder if different places are prescribing differently?

GoldfinchesInTheTree · 15/02/2025 04:16

But yes do see OP isn't doing the full 5mg.

Choux · 15/02/2025 07:48

GoldfinchesInTheTree · 15/02/2025 04:15

I'm not sure you're "supposed" to move up every month? All the advice I've seen suggests you stay at the lowest you can with weight loss as once you're at the top there's "nowwhere to go", other than the 2.5 dose which is just a springboard Rd to 5?

Ie if you're losing on 5 you stay on 5 until you're not?

Inwonder if different places are prescribing differently?

Yes but the OP is now saying she doesn't feel she is losing fast enough but is only on 4mg not 5.

HOWEVER OP you have lost 9kg in 6-7 weeks so that is about 20lbs. My starting weight was almost identical to yours and looking back I lost 12lbs in the same 6-7 week period so I think you have slightly unrealistic expectations of how fast you will lose the weight. To me you are a fast loser and have lost a lot of weight quickly.

If I were you I would make sure I was taking a multivitamin and eating well for nutrition - don't just eat smaller portions of the food that made you obese. Go to 5mg if you feel you need more suppression but otherwise just relax and aim to lose 1-2lbs a week for the rest of your journey.

InfoSecInTheCity · 15/02/2025 07:58

You are losing weight very fast, 9 kg in 6 weeks averages at 1.5 kg or 3 - 4 lbs a week,

1-2 lbs a week is a good solid consistent loss. You should expect and mentally prepare for your loss to be a long journey not a short sprint. There will be some weeks you lose more, some you lose less, some you lose nothing or even gain.

Mounjaro helps to make that long journey more doable, it helps to reduce the hunger which makes a diet usually feel interminable, so that you are able to maintain long term consistency with a calorie deficit. But Mounjaro itself does not make you lose weight, it helps to improve some hormonal responses that prevent excess glucose being stored as fat, but doesn't actually burn or reduce the fat you have. That is all you controlling your calorie intake.

Water, water, water. It's boring, hard to remember for some reason and always the habit I seem to drop most easily, but you need to have lots of it. Your body uses it to break down fat (lipolysis), your muscles use it to heal the small tears caused by increased exercise, if you are dehydrated then your body will prioritise retaining it to ensure it has enough, so if you do not drink you'll gain weight on the scales. It won't actually be fat but it can be disheartening to see the numbers. So drink plenty.

Dogsbreath7 · 15/02/2025 08:15

I started 10 mths ago at 96kg. Lost 6kg in 1 week! (Water of course). After that was pretty steady till 80kg then struggled to get below 80 for a few weeks. Had a weeks walking holiday and that kicked me down another 5kg. Then pretty much from Sept to dec I fluctuated between 72 and 69 kg and just couldn’t keep the downward trajectory. I did survive Xmas and 2 weeks all inclusive in that period so maybe that’s a technical win. Winter isn’t helping as long dog walks is my primary exercise so I am hoping spring will allow me to get rid of the final 10kg. Or my next milestone of 60kg. But 0.5kg loss in a week is eureka compared to despair of 1.5kg increase.

i would suggest upping exercise track what you eat rather than cut back calories. Yes you want a net deficit but as my walking holidays shows better thru exercise - and if you can do that on an empty stomach so body burns fat.

Goinghome2 · 15/02/2025 09:09

Dogsbreath7 · 15/02/2025 08:15

I started 10 mths ago at 96kg. Lost 6kg in 1 week! (Water of course). After that was pretty steady till 80kg then struggled to get below 80 for a few weeks. Had a weeks walking holiday and that kicked me down another 5kg. Then pretty much from Sept to dec I fluctuated between 72 and 69 kg and just couldn’t keep the downward trajectory. I did survive Xmas and 2 weeks all inclusive in that period so maybe that’s a technical win. Winter isn’t helping as long dog walks is my primary exercise so I am hoping spring will allow me to get rid of the final 10kg. Or my next milestone of 60kg. But 0.5kg loss in a week is eureka compared to despair of 1.5kg increase.

i would suggest upping exercise track what you eat rather than cut back calories. Yes you want a net deficit but as my walking holidays shows better thru exercise - and if you can do that on an empty stomach so body burns fat.

Did you wqlk on an empty stomach or takw extra calories to fuel you? I have a weeks walking holiday coming up and not sure what to do calorie and food wise.

Finallydoingit24 · 15/02/2025 09:34

Gettingslimmer · 14/02/2025 20:22

Um that is how it works, well they don’t disappear, but if they don’t regain then it is fatal, why do you think anorexia is fatal for some. Why they become skeletal. You cannot seriously think they just find a set point and stay there. Surely not?

and I’m already at 25 percent.

Confused

That’s good for you but typical weight loss is about 20% of starting weight according to the studies. Some will lose more, some less.

With the anorexics who don’t eat anything and suffer organ failure, that of course happens, but I was talking more of people who permanently eat less food than an average person their height and weight needs. They will not continue to lose beyond a certain point because the body adapts and it will slow down/stop at some point. So if I currently were to eat 1500 calories, I would lose weight but that won’t continue forever because my body will then adapt to survive on 1500 without letting go of further fat stores. Even though a different person of the same height and weight could probably easily eat 2000 cals and maintain their weight.
I know someone who has had a gastric sleeve. She was 25 stone and has lost 11st. She’s technically still obese but her surgeon says that further weight loss won’t happen as her body has stabilised. She can eat only small portions and her daily calories for a normal person would cause fast weight loss - probably around 1000 cals a day. But she’s now reached a point where she won’t continue losing.

Heydiddlediddlethe · 15/02/2025 10:04

Thanks for all these. It’s very useful. i’m not dissatisfied that i’ve not lost more but trying to work out why the difference when i seem to do what i did from week 1-5.
i have now taken a full dose of 5mg and the suppression is very strong but my issue is that i could probably go on for most of the day not eating anything which isn’t good and not realistic to sustain as a lifestyle. So ideally i want to get into a healthy 3 meal a day diet that still allows me to lose weight and can still feel the need to eat.
I know it may be too much to ask…

OP posts:
DarkForces · 15/02/2025 10:09

I've been on 5 a few months now and it gives me the balance you describe but took a while to settle in. My weight loss has slowed, but that's because I've had a bit of a relaxed few weeks and my daily calorie needs have decreased with my weight. It's a long haul journey and finding a balance takes time