Mounjaro not working

[StormingNorman]

I’ve been on Wegovy for a few months and it was brilliant. Barely any appetite at all. It’s £260 a month though so I thought I’d try MJ with all the good reviews it’s had and save myself a few £££!

I took my first 2.5mg on Wednesday and nothing. Not a sausage. Not even any side effects. In fact I took a second dose last night. Still nothing - no side effects or appetite suppression.

Anyone else it doesn’t work for? Should I persevere or go back to Wegovy?

It's not supposed to work on 2.5.
Some people are lucky but officially it's just to get your body used to the drug.
I wouldn't give up so soon.

If you've had 5mg in total now in your first week I'd watch out for side effects as that's a high dose to start on.

@Snozzlemaid Thats the weird thing. I haven’t had any side effects at all.

I have just switched from wegovy to mj and haven’t noticed any side effects nor have I lost any weight but I’m an goign to keep going for a few weeks

I think if you've been on a GLP1 before, it has less of an effect at the lower doses as your body has a certain amount of tolerance already. It may be that it doesn't work for you until 5mg or even 7.5. 2.5mg is just a loading dose and a lot of people don't lose weight on it. It didn't do much for me, but 5mg is working well.

I really wouldn't take more than the recommended amount, 2.5mg each week for 4 weeks. That's the initial dose, not everyone by a long way gets any suppression of appetite at this point. You really need to be patient and commit to a long term process. Then at each increase you should see a further effect.

What dose of Wegovy were you on and when was your last injection? Did you have the 5 week break before moving?

If you were on a higher dose of Wegovy it might take longer to feel Mounjaro is working.

Taking 2 x 2.5mg doses so quickly while you are still just in the beginning is taking a risk, you should speak to your provider or doctor before doing anything so reckless again.

I gained, yes gained, .4 lbs on my first month of MJ. Don’t worry about it, in the early stages some people lose, some maintain, some gain…it’s what happens over the long term that matters. I’m going into month 6 and lose about 1.5 lbs / week now. Slow & Steady is fine for me.

Edited to add - please follow the directions and let it work as it’s supposed to, it’s a powerful medication but you need to give it time to ramp up.

I started off with Orisliat tablet 3 x daily. But decided to move to mounjaro injections after 9wks, 2.5mg for 5wks and I only lost few lbs, just started 5mg today so hopefully notice difference this month but will keep going until reach ideal weight

I've moved from wegovy to mounjaro and gained initially as I had the 5 weeks break. I'm on 7.5 now and it's definitely kicked in!

1.7mg of Wegovy. My last injection was probably about six or seven weeks ago. I’d started some other new medication which was making me nauseous so I didn’t need to take the wegovy as I had no appetite anyway 😂

I don’t really think it’s reckless in my case to double up on a subtherapeutic dose. I had absolutely no response to the initial dose whatsoever so I probably don’t need to titrate as slowly as recommended. Especially as I had already been on similar medication for about 10 months.

Did you have to wait until 7.5 to get any effect?

Of course it is reckless, unless approved and monitored by a HCP. Your "case" is no different to any other new user of the medication who thinks its "probably" ok.

If you choose to be reckless fair enough, your body, but at least own it.

From what I've read and saw on various TT videos lots of people do not notice any appetite suppressant on the two lowest doses of MJ especially if they've been on a higher dose of wegovy previously. You've got to give it time to kick in and find the right dose for you op.

Ok. I’m not exactly overdosing on fentanyl 😂

Still not had any side effects and some small benefits starting today - food noise whitening down, not wanting to snack and my appetite has been smaller.

So it was a calculated risk worth taking 🤷‍♀️

I’m definitely a slow responder. I have seen some appetite suppression at each dose and the food noise is largely gone, but it only seems to last a couple of days. I’m up to 7.5 dose now and I can feel differences in my body but not seeing much on the scales yet.

I’m sticking with it for a bit as I do feel differences- hoping the scales catch up soon!

Thank you @Blink282! I had my third dose today and still nothing. If I was getting side effects at least there would be a point to this slow titration.

As it is I’m just putting on weight I’d already paid to lose on Wegovy while I wait it out switching medications.

At the moment I’m wishing I hadn’t bothered switching. I’ll just have to be patient although I might try to skip the next dose and go straight into a therapeutic dose.

I wouldn’t skip right up if i were you- 5 does seem to make people feel a bit crap for a while. But maybe titrate up slightly quicker- 5 or 6 days between doses rather than 7?

Have just weighed myself and I am actually 12lbs down in about 14 weeks. So not amazing but not nothing, especially as I have had the whole summer with holidays etc- i would normally put on that much over the summer!

Keep on keeping on x

Hi all. I’m wondering if anyone can give any advice or has a similar experience that they maybe able to share.
I was on ozempic a year or so ago and it didn’t work for me, meaning I had no side effects or appetite suppression. I got some advice to wait a while and try a different GLP1 medicine and have started using Mounjaro. The 3 weeks I had no suppression, side effects or weight loss. I’m fully aware that it’s a loading dose but given my past with another GLP1 medication I was worried that this may be a same experience as ozemic. My prescriber had a consultation with me discussed options and advised to start 5mgs 1 week early. I’m now approaching my 4th week on 5mg (so 7 weeks Mounjaro in total) and I still do not have any supression or side effects, I’ve lost a total of around 2lb in 7 weeks but I do feel it’s because I’ve been trying harder rather then it being from Mounjaro. Now I’m not in this for big weekly weight losses, as for me I can’t keep battling with my weight as o have done so since a teen (nearly 30 years). Slow and steady is key for me and the reason I’m looking to GLP1 medication for help is because I’ve tried every diet, calorie counting and even weight loss pills (not good or safe, ABSOLUTELY do not recommend) and after seeing so many positive reviews about this medication I hoped this would be the missing piece to the puzzle. I’ve done plenty of reading up and I do understand that it can take 8-12 weeks to get in to your system to create a steady state but as for some people who are slow responders they seem to still be feeling something and losing weight. I understand that there are some people who respond really well, within hours and see good weight losses (my husband being one of them 1st loss in 3 weeks). I understand there are factors for example if the heavier the weight the quicker it may come off for some. I’ve increased protein and I drink about 3l water anyway. I’m not comparing myself to others that have done really well as I know this helps everyone differently but I’m just so worried that I don’t hear stories like mine and worries me that it’s not going to work. I’ve ordered a 7.5mg pen to start next week, who knows if this will work better but I have set myself the task of sticking with this one upto around 20 weeks and if no suppression or results then I will stop, it’s not cheap mediation to keep up when there’s not benefits. Has anyone had an experience of this NOT working. Can MOUNJARO just not work for some people, can some people not respond to GLP1 medications at all:

any help would be greatly appreciated

@Gloryslife If you start a separate thread, your post will get more visibility and answers. Click on the general weightloss injections board link below and you'll find a button to click to start a new thread. Then you can copy and paste your post there.

https://www.mumsnet.com/talk/weight-loss-injections

Unfortunately it's true that these GLP1 medications just don't work for some people. I think it's possible around 10% of people that it doesn't work for. Don't think there is any research into why. Possibly the issue isn't with your GLP1 receptors, so there is nothing the medication can work on? That's a guess tho.

However, as ozempic is semiglutide and Mounjaro is trezepitide, there is still hope that the different medication might have an effect. Get up to 7.5mg/ 10mg and see how you feel.

If you get up to high doses and it still has no effect, then unfortunately it looks like you are one of the non responders.

I’m not sure but MJ still isn’t working for me. I’ve actually put weight on!

I did have good results with Wegovy so may have to suck up the higher price tag and go back to it.

If Wegovy worked for you, then MJ should start working at some point. What are you up to now? 7.5mg? Maybe 10mg will do the trick.

I would say starting on 2.5mg MJ would have been like starting on 0.25mg of wegovy. So you may just have to build up more to get the same effect that wegovy had on you. I think the wegovy had built up some tolerance for you, when though you are trying MJ now. Hopefully when you get up to a higher dose it starts working again.

@ObsidianTree thank for you for your reply, it’s really helpful. I will stay hopeful that the higher doses will be effective 🙏would love there to be more research as to why some people have non response to GLP1 meds. I’ve seen some mention of poor gut health and other health conditions, medication interactions but don’t feel like any of the reasons will apply to me. Anyway I will go with your advice and hope for the best!

@StormingNorman how long have you been using MJ?