Have used both. Skin and me suited me better.
However, I've not seen a great improvement and I still get skin peeling even 18 months in. I find both quite unpleasant on my skin.
As I progress through peri my skin is getting duller and more spotty (I am not that wrinkly but the fat fills it out;))
I don't want anything massively complex. I use a vit c serum am and then just a hydrating moisturiser pm and the tret every 2/3 days.