It didn't used to bother me too much when I was in my 20s/30s but I'm getting fed up now. My left breast is far too big for my 36E bra which fits my right breast perfectly. At a guess I'd say the left is three cup sizes bigger than the right and is floppy whereas the other is nice and pert. Fitted clothes always look untidy on me. I'd love to find a bra that would make me look less lopsided but I don't know if such a thing exists? I've even considered surgery to reduce the left breast in size although I'd imagine it's not an easy operation. I wouldn't consider having the right breast enlarged though.