Hiding some threads I'm not interested in on the Active Conversations list, I noticed that some threads I knew I hadn't opened were suddenly highlighted.
After some experimentation, it seems that the colour change is staying in the same place in the list when a thread is hidden instead of staying on the thread title. (see attached screenshots, where the highlighted title remains the 4th & 8th thread from the top)
I'm using Safari on a 2020 iPadPro running iPadOS 15.5 and with AdGuard installed, though the issue appears whether AdGuard is turned on or off.