Nabster,
Depression makes you want to be seperate, alone, away from anything and everybody. As others have said I know that feeling too.
Having been there, I know whatever I tell you at the moment, i,e It gets better, you can feel better etc... will just bounce of your brain. When you feel this lost and alone you cant imagine feeling any better.
I can tell you that at one of my lowest points to date this thread pulled me through.
Keep talking to us. We all care and want to listen to you.
What appointment did you miss today? Is that what has triggered this or is there anything else?