I think it’s easy to say “these people should be stopped from marrying and having children” when “these people” are not a group you’re personally ever likely to be a part of. When “these people” become autistic people, or people with Ehlers’s Danlos Syndrome, or another group your average MNer seems to be more likely to fall into, the view is suddenly that this is “easier to manage.”
nope, that was not my point.
the point is familial marriages are a genetically close match. Each partner donated one copy of each of their genes. Now with a history of familial marriage, it is likely both those genes are very similar. Having children with another family member and a child will inherit two very similar copies of a gene.
Which means there are no “fail safes” built in. In unrelated people who inherit two different copies, if one gene is faulty the other can step in, so there is no effect.
so when both your gene copies are similar, any slight issue will give rise to an effect. These effects cannot be predicted as it’s across all genes, it may be a cumulation of several mutations, or one.
what I meant be “easier to manage” is there is no way to tell whether a familial marriage will result in affected children, or what those effects may be. There are no tests, no cures, but the risk is much greater that there will be some effect.
unrelated marriages, even if there is a history of a genetic disorder, the genetics are clearer. So pre conception tests can be done, and if both parents carry that specific faulty gene you know the odds a child will be affected. If only one does again you can assess the risk and will know whether a child will definitely be affected, have a chance of being affected, or not.
”easier to manage” as in clinically. Hereditary diseases you can at least enter in to conception knowing how likely it is your child will be affected, and what those effects may be.
familial marriage and you are going in blind, no way of knowing if your children will be affected, mildly, seriously, at all.