I listen to the Friday Night Comedy podcast and I can honestly say that I only get to listen to The News Quiz all the way through without interruption about 5% of the time. The phone rings, someone knocks on the door, the dog needs to go out, the DC come back early, just now the cleaner turned on the hoover 5 mins in (I know, I know, my diamond shoes are too tight).
This does not happen with The Now Show! Or perhaps it does but I don't care as much because it's not as funny.