I've been prescribed it twice a day, pessaries 400mg. It drives me insane. It totally knocks me out within 2-3h. To the extent I have to go to bed and somehow regain my consciousness. It influences my work performance. Has anyone succeeded in getting the dosage down? I cannot find the right time to use it cause it will affect my morning or afternoon. I'm to use for another 10 weeks and there is no question of going off work. My midwife appointment is this week. But I reckon she cannot change my prescription. To I need to go to the EPU?