I know the preferred drug is Omeprazole, but was unable to pick up my prescription for it (dull story). I have Nexium, has anyone taken this in third trimester? From what I have read, Omeprazole contains Esomeprazole, plus another compound. I have horrendous GERD where I wake up essentially choking on stomach acid if I don't take it, burning my throat and lungs, else wouldn't be considering it. I'm in my 38th week of pregnancy.