MTHFR homozygous

[Conundrum12345]

Hi

Ive homozygous MTHFR mutation. My clinic has prescribed me 5mg of folic acid but I've been reading that it's a big no for homozygous MTHFR and methylfolate is better.

Is this true? Should I take 5mg of folate instead?

I'm due for FET in 7 weeks

This is a very specialist medical question that you would be much better asking your clinic than Mumsnet.
Best of luck with your pregnancy, I hope it all works out fine.

I tend to agree with @pbdr that this is very specialist, and you should raise any queries with your clinic.

Anecdotally, 12 years ago after 3x unsuccessful embryo transfers, I had detailed testing which showed me to be heterozygous for MTHFR, with IgG cardiolipin antibodies and lupus antibodies. I took high dose folic acid, prednisolone and heparin, and had a successful embryo transfer and have an 11-y-o daughter.

Best of luck to you for this cycle.

@Conundrum12345 I take methyl folate rather than folic acid - they do exactly the same thing in terms of you taking the supplement but your body has to turn the folic acid into folate before it can use it. I don't know if I have MTHFR but I did a lot of reading into it a few years ago when I was having issues with my urticaria which we think might be partly autoimmune. So I would agree that if you do have the mutation, you'd be better off with the methyl folate version. You'd need to double check to make sure you can get the same dose as you've been prescribed though.

Good luck OP 👍

Your body converts folic acid into methylfolate.

i was told I have that gene and they suggested a high dose 5mg of folic acid. They explained it’s because hopefully your body can concert at least some if it.

however I decided to buy 5mg methylfolate instead. I just got it from Amazon.