My little boy had constipation from 2 weeks old when we swapped from ready made to powder.. he has not been the same since he’s struggling with silent reflux constipation witch is on lactuloce for and permanently uncomfortable and unsettled.. I have only noticed the change in him since we used powder and we have also tried every powder and they all seam to be the same.. so I am thinking on going back to the ready made to see if that works.. has anyone had this problem ???