morning :)
elizabeth there is some evidence for some drugs not so much over the effectiveness, but that they're safe (i researched stuff that you could access for free, this preg :D ). There's a really reasusring article on Ondansetron here in the highly respected New England Journal of Medicine. Big study size too, which is better than the like .. 50 or so people I think it was .... where they found that Ondansetron might increase the risk of cleft palate. The huge study didnt find any risk increase at all. Not been able to find so much stuff on the other drugs, but the older anti-histamines and B6 have been used for many many years now. I think some of the other medicines don't have such a long use-record but not so sure on that.
This is for adverse fetal outcomes. In truth there - is- the possibility of longer term effects that are not known (ondansetron has only been used for preg sickness for about 10 years or so) but then, firstly there can be serious problems if you can't keep liquids / food down and secondly, in all truth if you never try anything new then well, no new drugs will ever be found. It's hard, but sometimes you have to take a (small) risk. Thalidomide would never have been licensed now anyway, cause the testing procedures are far better.
Not exactly what you were looking for sorry, not really the effectiveness thing, but something maybe? :)
tallyra i actually emailed a major HG researcher in the US, one of the founders of the HER forums here about the whole hormone / migrane / cystitis thing but got no reply, sadly.
mrsb the dizziness is an arse ...
and welcome booboo :) ye, I think we all reckon that the intense nausea is worse than the actual vomitting :s It drains you doesnt it? About hints on things to help, no doubt you already know the eat little, eat often thing? an empty stomach can actually make the nausea worse. And eat what you fancy, don't worry about appalling diet, lots of lived off food we'd never have gone near given a choice.
The drink thing is important. Lots of people find sparkling drinks help - sparkly water, lucozade, etc. lucinda found flat diet coke really helped. Sometimes sipping somethign either very hot or very cold helps, even sucking ice cubes.
Ye, the sickness coming back in the last trim seems to be quite common. Was it lighter than the first months' sickness? I'm in the last trim atm and getting sicker again, little bit worse each night bleh. Back to being in bed at 6pm, though at least it's not like ... 11am .. which it was at its worst. Roll on childbirth ... !