Ive been wearing them during the day since Friday , and have noticed a slight difference, as in not retching up(yes TMI I know). Ive noticed I have a bruised tender like feeling in both my hands were the the thumb meets the hand. I thought it was may be I had slept on my hands, but the pain is in both hands in the same area. I dont wear the bands at night, but is it to much to have them on all day? Its just I prefer not to be running to the loo 5 times a day or more.