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WARNING re dog flea treatments

85 replies

SchnozzaHoomum · 11/08/2025 11:56

I’m posting this because I just saw a thread from a year ago, stating that fleas become resistant to Frontline Plus, and recommending dog parents to “use the stuff the vet gives you instead”.

First of all, the story about drug-resistant fleas is an urban myth and is categorically untrue. Frontline Plus has been used safely and effectively over thirty years. You must apply it properly every 28 days. But it is extremely effective and completely safe for your pet. If you still have flea issues after use, you must wash thoroughly all soft furnishings and start keeping yoir dog clean.
My main reason for posting is the horror I felt when I saw dog parents being advised to use Nexgard / Simparica / Bravecto / Credelio.

PLEASE READ THIS BEFORE GIVING ANY MORE OF THESE DRUGS TO YOUR DOG.
I have spent the last two years doing intensive research, reading up on my own, speaking with other dog mums and dads and also with a consultant at a London vet hospital and our own vet.
All of the above four prescription-only drugs contain an active ingredient which ends in the letters, L A N E R. It might be Axfolaner or Sarolaner or something similar, but they are all from the same family. This is an extremely aggressive ingredient. When you give your dog their “tasty, chewy tablet” each month, you are topping up the significant residue that remains in their body after the previous dose. It can take months or years for their body to reach its limit. With our little schnauzer, it took four years of Nexgard for her to suddenly have violent cluster seizures. Her brain scan showed no epilepsy, and the consultant told us it was extremely rare for a dog of seven years old to suddenly develop epilepsy. This consultant also said it was “more likely than not” that our dog’s attacks were a result of the build-up of Axfolaner / Sarolaner in her little body. We took her off this stuff immediately and put her back on Frontline Plus, which worked perfectly well for the first three years of her life. Frontline Plus, Spot On and their worming tablets - NOT prescription ones, I mean the ones you buy off the shelf at the big pets’ chain store - are the safest and most effective way to prevent and kill fleas, ticks, mites and worms in yoir dog. I researched the active ingredients in these - Fipronil and (S)-methoprene. Their safety record is exemplary. Please do some reading up yourself, but bear in mind that every time you give your dog their Simparica or Nexgard, you are creating a ticking time bomb. The only reason there aren’t tens of thousands more anecdotal cases published is that vets refuse to acknowledge the connection between seizures and the drugs they make a fortune from. By all means disregard this. But I feel better sharing. We know of five dogs in our area alone whose parents believe these drugs have caused neurological reactions. Go safe, and stick to the tried and tested ones that don’t need vets’ prescriptions.

OP posts:
Blinkingbother · 09/09/2025 13:35

We also stopped using the spot on treatments when we discovered their environmental impact. It’s really horrifying!

ForeverDelayedEpiphany · 09/09/2025 13:52

SchnozzaHoomum · 09/09/2025 13:18

Thank you for your informative comments. Clearly, you know a lot more than most about this topic. I was stunned at the responses I received. We were told by a vet and a vetinary neurologist that Nexgard and Simparica were the likely cause of seizures in our dog. There are so many people with very low IQs on this site, that

You're definitely correct. All these are potent neurotoxic drugs, and affect the central nervous system. Basically, the first antipsychotic drugs were derived from pesticides / insecticides which affect the way the central nervous system functions hence the damage caused.

I should know, living for a decade with this stupid movement disorder 😢

Anyway... the ingredients in the flea treatments are most likely to be similar. I was gaslighted by four different neurologists before one confirmed that I have the movement disorder. Many people don't like acknowledging these drugs cause harm.

SchnozzaHoomum · 10/09/2025 14:45

allwells · 17/08/2025 16:33

This exact thing happened to my dog. We saw a newly qualified vet at the practice who said he probably shouldn’t be on these chewy tablets as he has seizures !!!! Seizures that started after taking these and he had tests to see if he had epilepsy! He was put on EpiPhen which didn’t stop the seizures . Thank goodness the newly qualified vet told me .

Get your vet to check your dog’s neutrophil levels on the epipen. Is it Phenobarbital? This is also extremely aggressive and reduces the white blood cell count. Our dog had to move to Levetiracetam, which is much safer and gentler. Still works.

OP posts:
SchnozzaHoomum · 10/09/2025 14:51

bumbaloo · 11/08/2025 20:35

There is massive regulation. What are you talking about. Do you always just accept what someone random online tells you?

Frontline contains fipronil which is so toxic to the environment that it is banned in agriculture in much of the world. It is hugely toxic to aquatic life and the bee population.

The risk to a healthy animal of isoxazoline ( the ingredient in question in Nexguard) extremely rare. All medications will affect a small group of people and animals adversely. That doesn’t mean they are a bad drug. It just means for that small group a less effective but safe for them product has to be used.

Bumbaloo, hadn’t even properly read my post. The “ingredient is question” is AFOXOLANER. It is this “laner” family of drugs which are dangerous. Also, I am not just some random person. I have lived this experience and have been told by a vet and a veterinary neurologist that the LANER drugs our dog had had caused her seizures. There are plenty of other anecdotal examples online. It would appear there are utter halfwits on here who believe absolutely everything a pharmaceutical company tells them is always true. Usually, prescription drugs are perfectly safe. But may I remind you about OxyContin?

OP posts:
ThisCanFuckOffToo · 10/09/2025 14:55

I don’t habitually flea my dog as it’s so bad for the environment and in 5 years he’s had fleas ONCE, was treated with frontline and they vanished.

You can do worm counts on any animal and, again, treat worms if required.

Over medicating animals is a vet led swiz.

Needanadultgapyear · 14/09/2025 08:35

As an owner of a dog with seizures and a vet I spent quite a bit of time talking to my veterinary neurologist about management including flea treatment in my own dog. My own dog is a water dog and I live in a rural area with a diverse wild life population that I am keen to support.
All animals and humans have an individual seizure threshold and this is lower in those prone to seizures than others, then other things can further lower the threshold including heat and stress.
All flea treatments have neurotoxicity actions that is how they kill the fleas and they are all recognised to lower the seizure threshold in individuals who are prone to seizures.
For my own dog I need to balance his health, risks and my environment so I choose to give him Simparica Trio as I feel the joy swimming and paddling brings to his life is far greater than the risk the tablet poses.

I happily discuss this and environmental risks with my clients. Though most clients just don’t want fleas, ticks or worms and do not want a discussion.
Every medication has side effects and as a pet owners I would encourage you to read the data sheet of any medication your pet is given and also read the data sheet of any medication you are given.

Summertimeflowers · 04/12/2025 21:52

Just found this thread and thought it interesting. My Vet changed my dog from Milpro to Simparica 3 months ago. He’s a 4 y/o GR and had his first ever seizure 2 days ago. It’s currently being treated as something he’s ate by our vets but now I’m wondering if it’s related to the change in medication. Think I’ll be asking to go back to Milpro moving forward.

Girliefriendlikespuppies · 04/12/2025 22:15

I use bravecto on the cat and dog, the cat is the one that gets fleas and frontline definitely stopped working on her.

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