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WARNING re dog flea treatments

85 replies

SchnozzaHoomum · 11/08/2025 11:56

I’m posting this because I just saw a thread from a year ago, stating that fleas become resistant to Frontline Plus, and recommending dog parents to “use the stuff the vet gives you instead”.

First of all, the story about drug-resistant fleas is an urban myth and is categorically untrue. Frontline Plus has been used safely and effectively over thirty years. You must apply it properly every 28 days. But it is extremely effective and completely safe for your pet. If you still have flea issues after use, you must wash thoroughly all soft furnishings and start keeping yoir dog clean.
My main reason for posting is the horror I felt when I saw dog parents being advised to use Nexgard / Simparica / Bravecto / Credelio.

PLEASE READ THIS BEFORE GIVING ANY MORE OF THESE DRUGS TO YOUR DOG.
I have spent the last two years doing intensive research, reading up on my own, speaking with other dog mums and dads and also with a consultant at a London vet hospital and our own vet.
All of the above four prescription-only drugs contain an active ingredient which ends in the letters, L A N E R. It might be Axfolaner or Sarolaner or something similar, but they are all from the same family. This is an extremely aggressive ingredient. When you give your dog their “tasty, chewy tablet” each month, you are topping up the significant residue that remains in their body after the previous dose. It can take months or years for their body to reach its limit. With our little schnauzer, it took four years of Nexgard for her to suddenly have violent cluster seizures. Her brain scan showed no epilepsy, and the consultant told us it was extremely rare for a dog of seven years old to suddenly develop epilepsy. This consultant also said it was “more likely than not” that our dog’s attacks were a result of the build-up of Axfolaner / Sarolaner in her little body. We took her off this stuff immediately and put her back on Frontline Plus, which worked perfectly well for the first three years of her life. Frontline Plus, Spot On and their worming tablets - NOT prescription ones, I mean the ones you buy off the shelf at the big pets’ chain store - are the safest and most effective way to prevent and kill fleas, ticks, mites and worms in yoir dog. I researched the active ingredients in these - Fipronil and (S)-methoprene. Their safety record is exemplary. Please do some reading up yourself, but bear in mind that every time you give your dog their Simparica or Nexgard, you are creating a ticking time bomb. The only reason there aren’t tens of thousands more anecdotal cases published is that vets refuse to acknowledge the connection between seizures and the drugs they make a fortune from. By all means disregard this. But I feel better sharing. We know of five dogs in our area alone whose parents believe these drugs have caused neurological reactions. Go safe, and stick to the tried and tested ones that don’t need vets’ prescriptions.

OP posts:
Newfluff · 11/08/2025 19:52

Ticks are a massive problem near me, frontline doesn't protect against them.

Also agree about spot ons being dreadful for the environment.

The increase of dogs being shipped from abroad means the need for vaccines such as Parvo is great now than ever.

Gothamcity · 11/08/2025 19:53

MrsLizzieDarcy · 11/08/2025 18:53

I've not flea treated or wormed my dogs, aged 12 and 6 since one of them had a horrid reaction to a Bravecto tablet.

And since we've stopped, they've never had fleas or worms.

I've also found this, although I do use indorex around the house every 6 months or so, as we did notice the odd flea after we moved house. I don't like putting flea stuff (unless totally necessary) on them as we have young children who forget not to touch them if we've ever applied it in the past. We have a very furry, long haired cat who has an almost candy floss like undercoat, I have to take outside to brush once a week and I'd hate to think his fur, that other animals may use to build nests, could be full of toxic chemicals. We don't ever get fleas. If I did notice them, I'd redo the house before I resorted to treating the animal.

bumbaloo · 11/08/2025 19:57

Frontline has problems. Firstly fleas and ticks HAVE built up tolerance whether you think so or not.

The active ingredient in frontline, Fipronil poses significant environmental risk especially to bees and aquatic life.

High Toxicity to Aquatic Invertebrates: Fipronil is extremely toxic to a wide range of aquatic invertebrates, including insects like mayflies and stoneflies, as well as crustaceans like shrimp and water fleas. Studies have found that fipronil and its breakdown products are often present in streams and rivers at levels that are toxic to these sensitive species, which are a critical part of the food web.

Persistence and Accumulation: Fipronil and its metabolites (the chemicals it breaks down into) are known to be persistent in both soil and water. This means they don't break down quickly and can accumulate in the environment over time, leading to long-term exposure for wildlife. Some of its breakdown products are even more toxic than the original compound.

Contamination Pathways: The primary way fipronil from pet treatments enters the environment is through wastewater. When a treated pet is bathed or swims, the chemical can wash off and go down the drain, eventually making its way to local waterways. Runoff from yards where treated pets spend time can also contribute to contamination.

Impact on Non-Target Insects: Fipronil is highly toxic to bees and other beneficial insects. While its use as a pesticide on crops has been restricted or banned in some places, its use in pet products remains a significant source of environmental exposure.

Regulatory Actions: Due to these concerns, the use of fipronil in agriculture has been restricted or banned in some regions, including the European Union, to protect honeybees and other non-target organisms. This highlights the scientific consensus on its environmental harm.

The risk of seizures in otherwise healthy pets is extremely rare. All medications are inappropriate for a small group of people/animals and fur them alternatives need to be used but for the vast majority, the newer treatments are more effective, safe and not as toxic to the environment

BoredZelda · 11/08/2025 19:59

Two years of research to discover what a cursory google search will tell you?

That self resolving neurological effects can occur in fewer than 10 in 10,000 dogs, (fewer still where there are no pre-existing neurological conditions)?

Or was your “research” about the conspiracy theory that “big vet” are pretending it doesn’t happen?

How’s that job at Frontline’s PR dept going?

MonCoubousMonTourmalet · 11/08/2025 20:09

MrsLizzieDarcy · 11/08/2025 19:25

The only thing mine have is the Lepto vaccine, and I'm seriously questioning that now my older one has slowed down and stopped diving head first into rancid water. But that's another can of worms, isn't it.

Our dog died from the Lepto vaccine. A healthy 7 year old.

NaeRolls · 11/08/2025 20:12

I'm so sorry that happened to your dog. Thank you for warning us. I'm a cat owner but a few of those brands also have cat versions, in fact the vet suggested Nexguard to me recently. I will stick with spot-on now. Awful how there isn't proper regulation of this industry. It's all about money. At least there are good vets out there though, my friend has given me the details of her vet who she says is honest and truly cares for the animals. I'll see her next time.

Btowngirl · 11/08/2025 20:21

Op, our GR randomly started having seizures as a puppy & the use of simpacara trio was potentially the cause. I do find the whole thing interesting, I have two friends whose dogs are being treated for epilepsy (which is how they treated ours initially) which seems a lot just in our circle? All large breeds (labs/GRs).

SparklingSparkles · 11/08/2025 20:26

Thank you for posting. I am worried now after reading this. Vet advised Simparica a month ago which I administered (I had not heard of it before) I gave second dose yesterday. I hate having to give my dog anything like this but thought it might be better than advocate which seemed to irritate skin. I trusted the vet and now I’m thinking I shouldn’t have done. Can’t trust anyone these days. I hope a vet or veterinary nurse will see this thread and share their point of view,

whoboo · 11/08/2025 20:30

TBF never had a problem when I had a dog tbh. Bloody cat though, nightmare, she doesn't even go outside. I for one can say frontline is bloody useless for cats at least.

bumbaloo · 11/08/2025 20:35

NaeRolls · 11/08/2025 20:12

I'm so sorry that happened to your dog. Thank you for warning us. I'm a cat owner but a few of those brands also have cat versions, in fact the vet suggested Nexguard to me recently. I will stick with spot-on now. Awful how there isn't proper regulation of this industry. It's all about money. At least there are good vets out there though, my friend has given me the details of her vet who she says is honest and truly cares for the animals. I'll see her next time.

There is massive regulation. What are you talking about. Do you always just accept what someone random online tells you?

Frontline contains fipronil which is so toxic to the environment that it is banned in agriculture in much of the world. It is hugely toxic to aquatic life and the bee population.

The risk to a healthy animal of isoxazoline ( the ingredient in question in Nexguard) extremely rare. All medications will affect a small group of people and animals adversely. That doesn’t mean they are a bad drug. It just means for that small group a less effective but safe for them product has to be used.

Testerical · 11/08/2025 20:42

There is a vibrant community of veterinary medicine misinformation peddlers online. I was shocked to find anti-scientific rhetoric affected dog health as well as people health.

There are known and notified risks from -laner drugs. They are judged to be lesser than the risks from the diseases and infestations they prevent. That’s the whole point of medicines. No one says they’re harm free - they are just on balance less harmful than leaving all dogs unprotected.

Lyme disease, angiostrongylus, etc - frontline is useless for and a major environmental contaminant as others have pointed out.

SchnozzaHoomum · 12/08/2025 09:23

sandgrown · 11/08/2025 19:42

I find it hard to take your post seriously when you refer to yourself as your dog’s parents ! We used Seresto for many years and found it very effective.

Are you a dog mum yourself?

OP posts:
SchnozzaHoomum · 12/08/2025 09:26

bumbaloo · 11/08/2025 19:57

Frontline has problems. Firstly fleas and ticks HAVE built up tolerance whether you think so or not.

The active ingredient in frontline, Fipronil poses significant environmental risk especially to bees and aquatic life.

High Toxicity to Aquatic Invertebrates: Fipronil is extremely toxic to a wide range of aquatic invertebrates, including insects like mayflies and stoneflies, as well as crustaceans like shrimp and water fleas. Studies have found that fipronil and its breakdown products are often present in streams and rivers at levels that are toxic to these sensitive species, which are a critical part of the food web.

Persistence and Accumulation: Fipronil and its metabolites (the chemicals it breaks down into) are known to be persistent in both soil and water. This means they don't break down quickly and can accumulate in the environment over time, leading to long-term exposure for wildlife. Some of its breakdown products are even more toxic than the original compound.

Contamination Pathways: The primary way fipronil from pet treatments enters the environment is through wastewater. When a treated pet is bathed or swims, the chemical can wash off and go down the drain, eventually making its way to local waterways. Runoff from yards where treated pets spend time can also contribute to contamination.

Impact on Non-Target Insects: Fipronil is highly toxic to bees and other beneficial insects. While its use as a pesticide on crops has been restricted or banned in some places, its use in pet products remains a significant source of environmental exposure.

Regulatory Actions: Due to these concerns, the use of fipronil in agriculture has been restricted or banned in some regions, including the European Union, to protect honeybees and other non-target organisms. This highlights the scientific consensus on its environmental harm.

The risk of seizures in otherwise healthy pets is extremely rare. All medications are inappropriate for a small group of people/animals and fur them alternatives need to be used but for the vast majority, the newer treatments are more effective, safe and not as toxic to the environment

Your post has been copied and pasted from tinternet, correct? I am just discovering the dangers to the environment of Fipronil. I had no idea about this. I am also looking into natural solutions, of which there are a myriad available.

OP posts:
Vintagenow · 12/08/2025 09:29

Lol. Tell me you're not a rep for frontline without telling me you're not a rep for frontline 😂 sales falling?

SchnozzaHoomum · 12/08/2025 09:30

Testerical · 11/08/2025 20:42

There is a vibrant community of veterinary medicine misinformation peddlers online. I was shocked to find anti-scientific rhetoric affected dog health as well as people health.

There are known and notified risks from -laner drugs. They are judged to be lesser than the risks from the diseases and infestations they prevent. That’s the whole point of medicines. No one says they’re harm free - they are just on balance less harmful than leaving all dogs unprotected.

Lyme disease, angiostrongylus, etc - frontline is useless for and a major environmental contaminant as others have pointed out.

The -laner family of drugs is (fact) very aggressive, creates a buildup of toxins in the dog’s body and is excessively potent in comparison to the risk the dog encounters. It’s Big Pharma for dogs. Makes an absolute fortune for the pet health industry. It’s like weight loss drugs for humans. What a goldmine. People too lazy to eat less and exercise will happily take a drug to get the weight off. Why would they NOT make a weight loss drug?

OP posts:
Testerical · 12/08/2025 09:36

Yes yes, I know about big pharma and overmedication. Still give my dog -laner drugs. There are no natural potions that effectively protect against tick borne diseases or angiostrongylus so I’ll save you the bother of going down the dorwest homeopathy wormhole (no pun intended).

You can wormcount if you want, but you’ll still need drugs if worms found and it might be too late to treat angiostrongylus.

SchnozzaHoomum · 12/08/2025 11:30

Testerical · 12/08/2025 09:36

Yes yes, I know about big pharma and overmedication. Still give my dog -laner drugs. There are no natural potions that effectively protect against tick borne diseases or angiostrongylus so I’ll save you the bother of going down the dorwest homeopathy wormhole (no pun intended).

You can wormcount if you want, but you’ll still need drugs if worms found and it might be too late to treat angiostrongylus.

Oh good lord, no, I will be continuing with the wormer tablets.

OP posts:
SchnozzaHoomum · 12/08/2025 11:32

Vintagenow · 12/08/2025 09:29

Lol. Tell me you're not a rep for frontline without telling me you're not a rep for frontline 😂 sales falling?

I am a secret Frontline PR guru. I even have pants with the Frontline logo 🤩

OP posts:
SchnozzaHoomum · 12/08/2025 11:33

bumbaloo · 11/08/2025 20:35

There is massive regulation. What are you talking about. Do you always just accept what someone random online tells you?

Frontline contains fipronil which is so toxic to the environment that it is banned in agriculture in much of the world. It is hugely toxic to aquatic life and the bee population.

The risk to a healthy animal of isoxazoline ( the ingredient in question in Nexguard) extremely rare. All medications will affect a small group of people and animals adversely. That doesn’t mean they are a bad drug. It just means for that small group a less effective but safe for them product has to be used.

Fipronil is safe for dogs and cats. The active ingredient in Nexgard / Simparica is not. It’s a choice. Protect your pet or protect the insects.

OP posts:
MrsSkylerWhite · 12/08/2025 11:34

K0OLA1D · 11/08/2025 18:43

Front line stopped working for my cats.

I now use advantage. Best flea treatment I've ever used.

Exactly the same. Also supplement with flea collars and repellent treats.
Presumably fleas evolve just like everything else.

SchnozzaHoomum · 12/08/2025 11:40

BoredZelda · 11/08/2025 19:59

Two years of research to discover what a cursory google search will tell you?

That self resolving neurological effects can occur in fewer than 10 in 10,000 dogs, (fewer still where there are no pre-existing neurological conditions)?

Or was your “research” about the conspiracy theory that “big vet” are pretending it doesn’t happen?

How’s that job at Frontline’s PR dept going?

Clearly, your Google search didn’t inform you of the growing number of dog parents whose healthy dogs have mysteriously developed seizures after using
-laner drugs.

The neurological effects are anything but “self-resolving”. You haven’t read anything about this. These are dogs who develop lifelong neurological conditions as a results taking these specific drugs. It was not a simple Google search.

I realise many dogs will be fit and healthy while taking these drugs. However, the drugs are excessively potent for the job they do in terms of what they do to a fog’s body. And also, cases of seizures are not reported as being linked to the drugs. They just claim it is unlinked.

In relation to your query about my job at Frontline, as I have explained to another poster, I am a secret Frontline spy. I even wear pants bearing their logo.

You stressed mums are so much fun 🤣

OP posts:
MrsSkylerWhite · 12/08/2025 11:42

You stressed mums are so much fun 🤣

Probably not half as much fun as “dog mums”. Tinkly laugh.

SchnozzaHoomum · 12/08/2025 11:43

MrsSkylerWhite · 12/08/2025 11:42

You stressed mums are so much fun 🤣

Probably not half as much fun as “dog mums”. Tinkly laugh.

Definitely not. Dog mums rule 👍

OP posts:
tripleginandtonic · 12/08/2025 11:43

My dog has had nexguard for 8 years and no seizures. Loves his chewy treat as you call it He's a dog, not a human so I am not his mum.

MrsSkylerWhite · 12/08/2025 11:43

SchnozzaHoomum · 12/08/2025 11:33

Fipronil is safe for dogs and cats. The active ingredient in Nexgard / Simparica is not. It’s a choice. Protect your pet or protect the insects.

In the long term, insects are vital. Pets, probably not so much.

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