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WARNING re dog flea treatments

85 replies

SchnozzaHoomum · 11/08/2025 11:56

I’m posting this because I just saw a thread from a year ago, stating that fleas become resistant to Frontline Plus, and recommending dog parents to “use the stuff the vet gives you instead”.

First of all, the story about drug-resistant fleas is an urban myth and is categorically untrue. Frontline Plus has been used safely and effectively over thirty years. You must apply it properly every 28 days. But it is extremely effective and completely safe for your pet. If you still have flea issues after use, you must wash thoroughly all soft furnishings and start keeping yoir dog clean.
My main reason for posting is the horror I felt when I saw dog parents being advised to use Nexgard / Simparica / Bravecto / Credelio.

PLEASE READ THIS BEFORE GIVING ANY MORE OF THESE DRUGS TO YOUR DOG.
I have spent the last two years doing intensive research, reading up on my own, speaking with other dog mums and dads and also with a consultant at a London vet hospital and our own vet.
All of the above four prescription-only drugs contain an active ingredient which ends in the letters, L A N E R. It might be Axfolaner or Sarolaner or something similar, but they are all from the same family. This is an extremely aggressive ingredient. When you give your dog their “tasty, chewy tablet” each month, you are topping up the significant residue that remains in their body after the previous dose. It can take months or years for their body to reach its limit. With our little schnauzer, it took four years of Nexgard for her to suddenly have violent cluster seizures. Her brain scan showed no epilepsy, and the consultant told us it was extremely rare for a dog of seven years old to suddenly develop epilepsy. This consultant also said it was “more likely than not” that our dog’s attacks were a result of the build-up of Axfolaner / Sarolaner in her little body. We took her off this stuff immediately and put her back on Frontline Plus, which worked perfectly well for the first three years of her life. Frontline Plus, Spot On and their worming tablets - NOT prescription ones, I mean the ones you buy off the shelf at the big pets’ chain store - are the safest and most effective way to prevent and kill fleas, ticks, mites and worms in yoir dog. I researched the active ingredients in these - Fipronil and (S)-methoprene. Their safety record is exemplary. Please do some reading up yourself, but bear in mind that every time you give your dog their Simparica or Nexgard, you are creating a ticking time bomb. The only reason there aren’t tens of thousands more anecdotal cases published is that vets refuse to acknowledge the connection between seizures and the drugs they make a fortune from. By all means disregard this. But I feel better sharing. We know of five dogs in our area alone whose parents believe these drugs have caused neurological reactions. Go safe, and stick to the tried and tested ones that don’t need vets’ prescriptions.

OP posts:
ChompandaGrazia · 12/08/2025 12:15

You stressed mums are so much fun

How rude. You might well have a point but no need to be so rude about it.

Where do you stand on receipts?

Testerical · 12/08/2025 20:34

you stressed mums? Bwahaha. What, are you a 16 year old killing time before GCSE results day or something??

Ylvamoon · 12/08/2025 20:41

... how about using flea treatment only when your pet actually has fleas?
better for the environment, the pets and stop being a cash cow for your vet

Confabulations · 12/08/2025 20:58

SchnozzaHoomum · 12/08/2025 11:33

Fipronil is safe for dogs and cats. The active ingredient in Nexgard / Simparica is not. It’s a choice. Protect your pet or protect the insects.

The pharmaceutical regulatory agencies don't agree with you. While there will always be risks for some individuals, on balance, the benefit:risk ratio is positive, or they wouldn't have been approved.
Regular pharmacovigilance reviews ensure that any addition identified risks are added to labels.

Branster · 12/08/2025 21:00

Dog mums, fur babies- ridiculous expressions and I can't take any grown up seriously when they use these terms.
Yes, topical treatments affect waterways and the environment in general. Also, if you use these on a dog that swims regularly, you might as well not bother because the substance will wash off.
There are risks with most treatments.
It is a balancing act. I do think that most pets do not need flea and tick preventative treatments all year around.

MarvellousMonsters · 14/08/2025 23:06

Mustbethat · 11/08/2025 19:13

Are you going to publish your research o/p?

two years is masters level, three would be a PhD. The norm would be to publish your findings in peer reviewed journals after that amount of “intensive research”.

I’m sure the scientific community would be very interested in what you’ve found.

No @Mustbethat, it was @SchnozzaHoomum that claimed to have done ‘extensive research’, not me. And as we both know this doesn’t mean in a lab, with huge statistically significant numbers peer reviewed etc. it means she’s googled a bit.

SchnozzaHoomum · 17/08/2025 15:36

MarvellousMonsters · 14/08/2025 23:06

No @Mustbethat, it was @SchnozzaHoomum that claimed to have done ‘extensive research’, not me. And as we both know this doesn’t mean in a lab, with huge statistically significant numbers peer reviewed etc. it means she’s googled a bit.

🤣 Who are you women who think “research” involves a “lab”? Clearly you have never written a dissertation or a thesis!

OP posts:
SchnozzaHoomum · 17/08/2025 15:37

Confabulations · 12/08/2025 20:58

The pharmaceutical regulatory agencies don't agree with you. While there will always be risks for some individuals, on balance, the benefit:risk ratio is positive, or they wouldn't have been approved.
Regular pharmacovigilance reviews ensure that any addition identified risks are added to labels.

👏 Well done on your googling and copy-pasting of multi syllables!

OP posts:
SchnozzaHoomum · 17/08/2025 15:37

Testerical · 12/08/2025 20:34

you stressed mums? Bwahaha. What, are you a 16 year old killing time before GCSE results day or something??

Erm … no … you’re SLIGHTLY off the mark there 😂

OP posts:
SchnozzaHoomum · 17/08/2025 15:38

ChompandaGrazia · 12/08/2025 12:15

You stressed mums are so much fun

How rude. You might well have a point but no need to be so rude about it.

Where do you stand on receipts?

Parding?

OP posts:
MysteryNameChange · 17/08/2025 15:53

MrsSkylerWhite · 12/08/2025 11:34

Exactly the same. Also supplement with flea collars and repellent treats.
Presumably fleas evolve just like everything else.

I'd be careful with flea collars. I tried one on my cat and he immediately went wobbly and weird and fell on his side. I took it off immediately. When I googled it, seemed a common story. They're totally unregulated.

sparkleghost · 17/08/2025 16:05

Anecdotally, our cat had a horrible reaction to Fipronil. He developed a horrible sore where it had been applied and lost a little patch of fur. I felt dreadful about it! It wasn’t Frontline that happened with though, it was Itch, a subscription company.

Advantage works a treat though, and I highly recommend Indorex for the house. It’s magic stuff.

marshmallowfinder · 17/08/2025 16:16

MrsLizzieDarcy · 11/08/2025 18:53

I've not flea treated or wormed my dogs, aged 12 and 6 since one of them had a horrid reaction to a Bravecto tablet.

And since we've stopped, they've never had fleas or worms.

You have no idea though that they don't have worms, unless you do a faecal test and even then it's fairly unreliable. De worming your dog routinely is really important, mainly for human health reasons.

ArmchairXpert · 17/08/2025 16:26

SchnozzaHoomum · 12/08/2025 09:30

The -laner family of drugs is (fact) very aggressive, creates a buildup of toxins in the dog’s body and is excessively potent in comparison to the risk the dog encounters. It’s Big Pharma for dogs. Makes an absolute fortune for the pet health industry. It’s like weight loss drugs for humans. What a goldmine. People too lazy to eat less and exercise will happily take a drug to get the weight off. Why would they NOT make a weight loss drug?

I was following this thread with interest... but OP you are seriously unhinged.

allwells · 17/08/2025 16:33

This exact thing happened to my dog. We saw a newly qualified vet at the practice who said he probably shouldn’t be on these chewy tablets as he has seizures !!!! Seizures that started after taking these and he had tests to see if he had epilepsy! He was put on EpiPhen which didn’t stop the seizures . Thank goodness the newly qualified vet told me .

FionnulaTheCooler · 17/08/2025 16:41

Frontline stopped working for my pets too, I get Bravecto now and it seems to be good. My last cat lived to 18 and never once had a seizure so you'll forgive me if I take your "advice" with a large pinch of salt.

Confabulations · 17/08/2025 20:50

SchnozzaHoomum · 17/08/2025 15:37

👏 Well done on your googling and copy-pasting of multi syllables!

🤦🏻‍♀️🤣🤣
Welcome to the fact that some of us are brighter and better educated than you. It is the world I work in. I don't need Google or C&P.

SchnozzaHoomum · 18/08/2025 19:56

Confabulations · 17/08/2025 20:50

🤦🏻‍♀️🤣🤣
Welcome to the fact that some of us are brighter and better educated than you. It is the world I work in. I don't need Google or C&P.

I can confidently say that neither you nor anyone who has interacted with my post is even remotely as intelligent as I am. Of that I am certain.

OP posts:
Mustbethat · 18/08/2025 20:31

SchnozzaHoomum · 18/08/2025 19:56

I can confidently say that neither you nor anyone who has interacted with my post is even remotely as intelligent as I am. Of that I am certain.

Dunning Kruger?

you have no idea of mine or pp “intelligence levels”, so there’s no way you can be certain you are more intelligent.

if you can draw such a definite conclusion without being in full possession of the data, which is research 101, how can you be as intelligent as you assert?

Caaarrrl · 18/08/2025 21:02

MysteryNameChange · 17/08/2025 15:53

I'd be careful with flea collars. I tried one on my cat and he immediately went wobbly and weird and fell on his side. I took it off immediately. When I googled it, seemed a common story. They're totally unregulated.

One of my cats also had a similar reaction to a seresto collar. Got him to vet straight away because it was so scary to see him like that. Vet said it was probably the collar and he got better when it was removed.

Confabulations · 18/08/2025 21:08

You admit to having no medical qualifications, whereas I do. I absolutely 100% guarantee you that I know a lot more about veterinary pharmaceutical R&D and regulation, including the 'laners' as you call them than you will have picked up from research googling, which you accused me of because I used words you didn't understand. Is your research published? Mine is.

By the way, you didn't spell afoxolaner correctly in your OP, then berated another PP for finding your grammar and syntax hard to follow and claimed it was perfect and no one would find a mistake.

I am sorry if your dog is one that has reacted to an isoxazoline. That does not mean that the overall drug class is unsafe for all dogs.

Holdingonfornow · 18/08/2025 21:17

bumbaloo · 11/08/2025 20:35

There is massive regulation. What are you talking about. Do you always just accept what someone random online tells you?

Frontline contains fipronil which is so toxic to the environment that it is banned in agriculture in much of the world. It is hugely toxic to aquatic life and the bee population.

The risk to a healthy animal of isoxazoline ( the ingredient in question in Nexguard) extremely rare. All medications will affect a small group of people and animals adversely. That doesn’t mean they are a bad drug. It just means for that small group a less effective but safe for them product has to be used.

This

Also imidocloprid which is in advocate, is also very bad for invertebrates

ForeverDelayedEpiphany · 08/09/2025 14:45

SchnozzaHoomum · 11/08/2025 11:56

I’m posting this because I just saw a thread from a year ago, stating that fleas become resistant to Frontline Plus, and recommending dog parents to “use the stuff the vet gives you instead”.

First of all, the story about drug-resistant fleas is an urban myth and is categorically untrue. Frontline Plus has been used safely and effectively over thirty years. You must apply it properly every 28 days. But it is extremely effective and completely safe for your pet. If you still have flea issues after use, you must wash thoroughly all soft furnishings and start keeping yoir dog clean.
My main reason for posting is the horror I felt when I saw dog parents being advised to use Nexgard / Simparica / Bravecto / Credelio.

PLEASE READ THIS BEFORE GIVING ANY MORE OF THESE DRUGS TO YOUR DOG.
I have spent the last two years doing intensive research, reading up on my own, speaking with other dog mums and dads and also with a consultant at a London vet hospital and our own vet.
All of the above four prescription-only drugs contain an active ingredient which ends in the letters, L A N E R. It might be Axfolaner or Sarolaner or something similar, but they are all from the same family. This is an extremely aggressive ingredient. When you give your dog their “tasty, chewy tablet” each month, you are topping up the significant residue that remains in their body after the previous dose. It can take months or years for their body to reach its limit. With our little schnauzer, it took four years of Nexgard for her to suddenly have violent cluster seizures. Her brain scan showed no epilepsy, and the consultant told us it was extremely rare for a dog of seven years old to suddenly develop epilepsy. This consultant also said it was “more likely than not” that our dog’s attacks were a result of the build-up of Axfolaner / Sarolaner in her little body. We took her off this stuff immediately and put her back on Frontline Plus, which worked perfectly well for the first three years of her life. Frontline Plus, Spot On and their worming tablets - NOT prescription ones, I mean the ones you buy off the shelf at the big pets’ chain store - are the safest and most effective way to prevent and kill fleas, ticks, mites and worms in yoir dog. I researched the active ingredients in these - Fipronil and (S)-methoprene. Their safety record is exemplary. Please do some reading up yourself, but bear in mind that every time you give your dog their Simparica or Nexgard, you are creating a ticking time bomb. The only reason there aren’t tens of thousands more anecdotal cases published is that vets refuse to acknowledge the connection between seizures and the drugs they make a fortune from. By all means disregard this. But I feel better sharing. We know of five dogs in our area alone whose parents believe these drugs have caused neurological reactions. Go safe, and stick to the tried and tested ones that don’t need vets’ prescriptions.

Hi OP, I'm not a vet or doctor but I do have a neurological involuntary movement disorder called tardive dyskinesia that was caused by some prescribed off label antipsychotic drug called Pericyazine.

i have read a few scientific articles about how the drugs like flea treatment work, as they are effectively the same as pesticides in their mechanism of action, and similar to what drugs like antipsychotics do.

From what I have experienced with cat flea treatment, I am extremely sensitive to these drugs as they make my neurological involuntary movement disorder symptoms much worse.

They also believe that pesticides can cause Parkinson's in some people, so it makee sense these drugs would affect people like me who are already injured from similar medication.

ForeverDelayedEpiphany · 08/09/2025 14:49

So I agree with you. Don't listen to the twits who won't believe you.

SchnozzaHoomum · 09/09/2025 13:18

ForeverDelayedEpiphany · 08/09/2025 14:49

So I agree with you. Don't listen to the twits who won't believe you.

Thank you for your informative comments. Clearly, you know a lot more than most about this topic. I was stunned at the responses I received. We were told by a vet and a vetinary neurologist that Nexgard and Simparica were the likely cause of seizures in our dog. There are so many people with very low IQs on this site, that

OP posts: