i do, we've split a bedroom and made ds's room smaller and a study for me. it's where i work from, and only finished decorating it at the weekend, carpet was fitted monday. its got a 'L' shaped desk with the computer and my sewing machine on, shelves with all my books on, lots of boxes full of thread, fabric, buttons, beads etc. need to put up a big noticeboard at the weekend.
dh has a wooden cabin in the garden as his studio. it all sounds very idylic doesn't it, but we've moved to a bigger house. prior to this dh rented studio space and it cost more than our mortgage once you'd included business rates. it was more economical to buy a bigger house and both of us work from home.