No, I wouldn't. Too many things add up to bother me. I might (MIGHT) consider it if it was for something like a two year contract, I knew it would be well paid with excellent health insurance and we 100% had something to come back to.
What worries me though:
Guns - I realise that is is still rather rare, but an increased chance of school shootings is terrifying and the idea that I'd have to brief my DC in gun safety (which I wouldn't know where to start) in case they ever came across one at somebody's house freaks me out. School shootings always seem to happen in places people say you would never expect it either.
Healthcare costs, even with insurance
Healthcare seeming massively influenced by profits and litigation culture - e.g. birth more medicalised, etc. Partly because that's a bit alarming but partly because it seems to encourage a dichotomy where a much higher percentage of people (than in the UK) get frightened away from doctors entirely and end up in places like the antivaccination movement.
Crap working rights
People going to work when they're sick - meaning you get ill more - crazy germophobia seems less crazy when you think about it that way.
No/very little maternity leave without losing your job (not even being a case of having the option to take longer unpaid) and childcare seems poorly regulated and expensive.
University crazily expensive
Extreme weather - hurricanes and storms and wildfires - I understand that's location dependent but it would put me off an area.
Religion - maybe I'm too grumpy and British.
Higher incidence of car crashes and car crash deaths not only by km driven but in general since cars are basically a necessity there, the driving test is less stringent and there is no mandated regular maintenance check.
Aggressive police/having to actively teach my sons to be scared of/defer to police. OK, we are white, this is likely to be minimal, but the culture is extremely different. I think it's crazy that a 17 year old could end up with a criminal record for being caught drinking for example.
General culture of having to supervise children at all times and lack of being seen as neglect, not just bad parenting but actual neglect worthy or reporting to CPS. Moving from the UK would be bad enough - moving from Germany would be awful having got used to the freedom kids have here.