Trying to conceive baby#2 following ivf treatment for #1

[lucieloos]

I thought I would start this thread as I can't see anything similar. We underwent many rounds of icsi and following a couple of bfns, and an ectopic pregnancy we were finally blessed with our beautiful daughter last year.

We recently started thinking about baby no 2 and had 4 frozen embryos of which 2 had been tested and found to be chromosomally normal so are meant to have a better chance. We didnt have the other 2 tested.

A couple of weeks back we had our first fet with one of the tested embryos and got a bfp super early at 4dp5dt. Sadly by 8dpt the line was barely visible and resulted in a chemical pregnancy. I've been feeling really down about it as this was meant to be a super duper embryo with no genetic problems which they said was the main reason embryos fail.

I thought it would be easier trying for #2 and of course it is in a way as I realise how lucky I am to have had a baby but I can feel the infertility fog starting to descend again as I realise although I've had a brief respite I will never be like my fertile friends and I do really want another baby and a sibling for my little girl.

Im feeling a bit negative at the moment. We will probably go back for the other tested embryo in the near future but I can't see how I would ever get lucky enough to get 2 bfps in a row. These things just don't happen to me so just not too hopeful about it at all. We said that if we used all of our frosties with no success we would be happy with what we have but already I am thinking should I do more fresh cycles. I will be 39 soon though so time isn't on my side for that.

Anyway just wondering if anyone else is in a similar situation and would like to share the journey. Please come and say hi.

Thanks @lucieloos and @Chocolateandwineplease27 - hello 

I'm 39 and said to myself I would give up when I'm 40, so you have time @lucieloos

Aww thanks twinkle yes I was hoping to have had the second by 40. Who knows I just hope this next one works. I'm so nervous about my transfer on Friday and going through it all again. I just know I'm going to feel so down if it doesn't work. I don't want to feel like that I just want to enjoy this year.

If this works out, I'll give birth the month before I turn 40!

I know what you mean about feeling down. I really wish you all the luck in the world

Thank you x

Hi everyone! Some familiar names on here. Just place marking as am starting to think about no 2. On the one hand I don’t really feel ready - I only stopped breastfeeding a month ago, I am still flabby and out of shape, and I started a new job in February so would be best to wait til next year - but on the other I deifnitely want number 2 feel distracted knowing that I will “have” to be pregnant again in the next 12 months so kind of want to get it over with

I’ve got loads of Frosties left but am still panicking about it all. Am very alarmed to see that both lucie and snow have had chemicals with PGS tested frosties- I thought that wasn’t meant to happen! And I’ve heard of this thing where mothers of boys have an immune reaction that means subsequent implantation fails and am (irrationally) terrified that will happen to me. Then am annoyed at myself for being a irritating drama queen. Back to infertility hell I guess! In any event I’m in uncharted waters as seem to be having utterly normal cycles since my period restarted in January (never ovulated beforehand - aggressive PCOS). Am on the minipill atm and it’s a weird thought that for the first time ever I might be able to get pregnant naturally if I tried!

twinkle congratulations! I wonder how many have stuck. You must be so happy.

Hopefully the first of many bfps!

Ahhh hi stealth lovely to see you here! That's great that you're starting to thinking about number 2. I remember you have lots of tested frosties left so hopefully you will be fine but I know what you mean it is uncharted as we don't know what if anything might have changed since no 1.

I went for intralipids in the uk last week and was talking to the consultant about pgs and she said that whilst the embryo may be chromosomally normally it's not the only factor in determining whether it will implant. There are other things on a deeper genetic level which can't be tested for at the moment. For instance the embryo needs to secrete the correct glucose levels which I guess is to do with its metabolism. If it doesn't then it simply doesn't have the energy to continue growing and will unfortunately fail. I think with a decent batch of tested embryos though this should be overcome as odds say by 2 or 3 transfers it should have worked. I'm still terrified of the next one now though. I thought with 4 frosties we were more or less guaranteed another baby but I should have known better!

Welcome stealth and thank you. Slightly freaking out about how many are in there!

I'm a mum of a DS so put your worries about having a boy and implanting to one side. No reason why it shouldn't work. Good luck

Hi lucie! Lovely to see you. Really sorry that your transfer failed - you really have had such a tough run. Keeping everything crossed for you this week.

I know it’s terrifying isn’t it? I know we are so lucky in terms of having lots in the freezer but it just puts me into panic. Really interesting re the PGS testing - I don’t recall anyone telling me any of that fine detail when we were paying bucket loads to have ours tested! Although we had to do the PGS as with 20 embryos we could have put a LOT of bad ones back without th testing. Still, how frustrating and stressful to know that PGS is no guarantee.

I guess we’ll do a natural fet this time round as I can very easily now pinpoint ovulation - all the things that always sounded so mysterious to me (ewcm, ovulation pain on one side, positive opks) I now have! I guess the big question is whether we just try naturally for awhile. Which is the obvious answer, actually, but dh is 48 and I am 36 and I do worry about the quality of our embryos at this point. It sounds weird but I’d be gutted to get pregnant and then have a mmc at the 12 week scan - at least with a PGS tested frostie you know that if you make it through implantation properly you’ll almost certainly be fine!

Yes I think you would definitely have needed to do pgs anyway. I asked the uk consultant her opinion on whether she thought it would be worth me doing it again if I had to do another fresh cycle and she said no unless I make lots of embryos which I don't. Apparently it doesn't increase implantation rates very much but as you have said it does decrease miscarriage rate which would still be a big benefit to me.

I loved doing the natural fet it was so much easier but decided to do medicated this time just incase I need the extra estrogen and it's something else to try differently.

Wow I can't believe all of us are thinking about a second at the same time! Is so nice to have company. It seems like everyone feels the same: not getting any younger, worried how long it will take etc. etc. I am 40 next month so feel I need to get on with it. Lucie I know what you mean about just wanting to enjoy life. I don't want these precious early years with DD to be overshadowed by TTC rollercoaster but am also desperate for another! Another reason I just want to get on with it is that I want to say goodbye to the TTC years! Forever! And get on with the rest of my life...

Yes definitely Jen I agree. If this transfer worked for us it would be so amazing and really change our lives. We could really enjoy this year and look forward to having the 2 babies we dreamed of. We would also still have 2 frosties left and whilst I would be more than happy to stop at 2 babies I would probably transfer the last 2 at some point so as not to leave them behind.

Is anyone else having a transfer soon or is it just me at the moment?

lucie I had 9 blasts, one was my son and then of the 8, 4 tested "normal". I'm glad we did pgs but still doesn't take the stress away! I'm 36 so guess I've still got time but the thought of doing a fresh cycle sends me into a panic!

Hi stealth - I remember we have the same doc. I'm going to see him soon to discuss a transfer/whether there's any tests he would recommend doing beforehand.... Have you seen him at all?

Re trying naturally, the issue seems to be with my husband and we've had a couple of early miscarriages so don't think we'll bother. I can't face that again!

I'm having a mild panic, could the positive be false and actually have been the trigger shot?

When did you take the trigger twinkle and how much did you do? Are your lines getting darker?

Choc that's a lovely number of blasts to have. Hopefully you should definitely have success with one of them or more! I know what you mean about a fresh cycle the though of doing another is not very appealing at all.

The trigger was Saturday 17 March.

I haven't tested again this morning as I have no tests in the house. I will order a digi.

It should definitely be out by now then. I would be tempted to pop out and get another frer just so you can check your line is darker.

The line was really dark yesterday. Will take a picture and post it when back home.

Oh ok didn't realise you had tested yesterday. That sounds fine then.

This is yesterday's test. Taken at around 4pm.

Looks good how many dpt is that?

8 days post 5 day transfer.

It looks good that wouldn't be the trigger

Ok thanks

Looks good to me twinkle! How exciting!!

Hi ladies, can I join you. TTC for #2. We didn’t have IVF with Our DD who is almost 10 months but with IUI. With Clomid and Ovitrelle' from the first try! I was 40 then! I’ll be 42 in 2 weeks! Am I the most ancient mama on here?
Anyway, last month went home (IVF clinic in Riga) for polyp removal and endo scratch, suffice to say, we didn’t do it but went for IUI instead. My dr warned me of IUI failure but we still went for it. And it was BFN. Gutted but knew it might not work. Just got back from home where my dr removed the polyp and I had endo scratch! That happened on CD9. We DTD yesterday and I’ve only just realised I’m in the middle of fertile window, ovulation usually happens cd14-16. I’m on CD14. Do we have a chance of falling pregnant this cycle? Or too soon after the scratch? Has anybody had experience with endo scratch?
We’re also booked for another IUI end of this month. And discussed IVF and apparently it will have to be with ICSI.
Congratulations twinkle! I did my bloods at 76 Wimpole Street, London. Same day results. You can book online and it’s cheaper!