I always take a ziploc bag with a few doses of all medications I can think of !
paracetamol, anti sickness, constipation tablets, Diarrhea tablets, rehydration sachets, antihistamine tablets, antiseptic wipes.
Ive been in too many precarious situations without medication so I’d rather not risk it now.
I also take a small microfibre towel rolled up - comes in handy for excursions rather than lugging a big thick beach towel around.
An insulated water flask so I don’t end up stuck with warm, plastic bottle water.
A universal adaptor and a small extension lead so I can charge or use multiple electrical items at once.
Depending on the type of trip, maybe a fire stick or similar for the tv. We had one all- inclusive where the evening entertainment was dreadful and you couldn’t really hide from it so we’d retire to the room with a drink to watch an episode of a good series before bed.
A wide brim straw hat that can be rolled up into suitcase.
Finally, I always travel with a rucksack with side pockets for a water bottle and sun cream - much more practical than a tote bag imo