Best airline London to San Fransisco

[WobblyLondoner]

I need to fly for work, for a short trip, hopefully premium economy. Need to be fully functioning from the outset and always struggle to sleep on flights!

Any recommendations for airlines welcome - BA, Virgin & Lufthansa seem the best in terms of timing.

Virgin is always good. I hate night flights though but day flights are very good. We've flown often with Virgin to see family and very satisfied.