We are considering the following next summer:
Fly to Vancouver
Vancouver island - prob Tofino? Maybe Orca Island? Want to see as much wildlife as possible
Seattle (?)
Portland
Cannon Beach
Not sure if it's doable in just over two weeks and what order is best? Happy to get ferries, trains, hire car, even do seaplane if price not £££
What we like to do and what teens like to do is different. 
We will definitely need to find teen friendly activities in each place. Have a DS that likes organised activities eg kayak tours, river tubing, wildlife spotting, watching live sports and a DD that likes shopping and wildlife.
Hoping to hire bikes where we can (Vancouver, Cannon Beach).
Recommendations welcome especially teen friendly activities, places to stay, order to do it in and recommended transport between!!!