My parents have a lovely villa in the Languedoc and we drive there often. We always go via Clermont Ferrand so know the journey well. We tend to do the outward leg in 2 parts (so that my husband need only take a half day holiday) and coming back all in one day so yes, it is do-able.
When we go, we get to Calais about 5.30pm, stop about 7pm for food and to get the children (5 & 2) into pyjamas and then drive to Orleans to stay over.
I reckon it'll take about 6.5 hours of driving, plus stops. So it depends how many times you stop, and for how long.
It is a pretty simple journey apart from going through Paris. You can go other ways, avoiding Paris, but it is further and takes quite a bit longer.
If you need simple directions, just let me know!