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Reflux/gastritis not responding to omeprazole??

32 replies

Ellie54320 · 09/10/2025 18:16

Just need someone to talk me down, no horror stories please as I’m already a nervous wreck. Just seeing if anyone has experienced anything like this…

A few months ago I started to feel like something was stuck in my throat the GP said Globus and it’s harmless so I went on my way. Then I started developing a slight cough (sometimes a bit croupy), my throat started becoming sore on and off and then I developed the burning/gnawing pain central under the ribs. GP said this was gastritis so put me on Omeprazole. That was an over month ago and I’ve been on 40mg but if anything it’s made me worse. I came off it for 2 weeks to go on femotodine (sp?!) and the stomach resolved slightly but the throat got worse?!

2 days ago I started Esomeprazole again and wham stomach pains now severe.

today I’m at my witts end … I’ve got a sore throat, lump feeling in throat, sometimes feel like I’m being strangled at the base of my throat, severe burning middle under ribcage, burping a lot, left ear keeps getting blocked, occasional cough,.. throat just feels irritated and angry and I can’t sit and do my job with the stomach pressure I have to keep getting up and walking about.

I just don’t understand why the omeprazole isn’t helping, but if I come off it my throat is SO much worse so I don’t know what to do.

No weight loss, no blood, stools okay, swallowing fine.

This is a long shot but has anyone had anything like this?! I’ve been referred by my GP for an endoscopy but it’s a really long wait so I’m just reaching out.

I’m 42, don’t smoke, drink a little.

Any help appreciated, I’ve convinced myself I’m at deaths door tonight and spiralling a bit with the wait.

OP posts:
Pixiedust1234 · 09/10/2025 23:59

JoLou321 · 09/10/2025 19:52

I haven’t experienced the same issue as you, but did suffer with reflux for a long period of time. I was constantly taking omeprazole, Gaviscon, Rennies etc. I now take apple cider vinegar tablets everyday and have never suffered from it since. I do have other intestinal issues which the reflux was a side effect of.
I would still request further tests to rule anything out but in the meantime apple cider vinegar may be worth a try to help with your symptoms.

That is the one thing I haven't tried yet. Can I ask what strength and brand you take for the apple cider please?

JoLou321 · 10/10/2025 12:29

Pixiedust1234 · 09/10/2025 23:59

That is the one thing I haven't tried yet. Can I ask what strength and brand you take for the apple cider please?

I’m taking 2x 300mg tablets in the morning. I’m on the Holland and Barrett ones at the moment, but have used other brands and they have all worked for me.
Good luck, I hope it helps!

Pixiedust1234 · 10/10/2025 14:09

@JoLou321 thank you!

WearyAuldWumman · 10/10/2025 14:11

I know that they're both proton pump inhibitors, but - for some reason - while Omeprazole doesn't work for me, Lansaprazole does. Might be worth asking your GP to try a switch?

Sugarahhoneyhoney · 10/10/2025 16:26

JoLou321 · 10/10/2025 12:29

I’m taking 2x 300mg tablets in the morning. I’m on the Holland and Barrett ones at the moment, but have used other brands and they have all worked for me.
Good luck, I hope it helps!

@JoLou321 do they make you more acidic to begin with?

I always pickled my red onions in ACV but stopped consuming it when I developed the reflux, perhaps I didn't need to?!

JoLou321 · 10/10/2025 20:56

Sugarahhoneyhoney · 10/10/2025 16:26

@JoLou321 do they make you more acidic to begin with?

I always pickled my red onions in ACV but stopped consuming it when I developed the reflux, perhaps I didn't need to?!

Mine was bad to start with so didn’t notice it being any worse. Although, I have heard that they can worsen it temporarily due to your stomach replacing it’s natural acid.

ForCraftyWriter · 10/10/2025 21:09

@Ellie54320 you don’t need the barium swallow.
You need to take gaviscon advance at the full dose after every meal. You can get it cheaper from online pharmacies. I was paying about £50 a month for a while. I’m surprised it hasn’t been suggested. No snacks between meals as you won’t have enough gaviscon.
Cut out coffee and fizzy drinks

I was on ppi and gaviscon advance for about 4 months and there was no improvement.

Then I started the curable app (for a different reason) 3 months ago and the reflux symptoms are much much better. I never have globus now, rarely chest pain and rarely the severe throat clawing pain. I do still have some symptoms remaining but I no longer need gaviscon and I’m reducing my ppi very slowly.

Could you try this?

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