One dose 10% protection!

[penni00]

The Telegraph, this evening, is saying one dose of AZ/Pfizer only gives 10% protection against the Delta.
Is this accurate?
I had AZ in March with prolonged nasty side effects, and may not be able to have any further vaccine. I feel 'damaged' by the vaccine, please tell me this is not all for just 10% protection?

can u link where you're seeing that reported please?

Is that relative risk or absolute risk?

It is important to understand what they mean exactly. Then you can decide how worried you want to be

Yes I saw that. 4 weeks after 2 doses gives very high protection though

The link won't work when I try to send it, I just tried sending it to someone else. I think it is because the Telegraph hide their articles unless you have a subscription. I took out a subscription for free, (only free initially).

It's not hard to believe, the JCVI has issued interim advice on COVID-19 booster vaccination:

www.gov.uk/government/news/jcvi-issues-interim-advice-on-covid-19-booster-vaccination

So basically, the current vaccines are losing effectiveness.

Have a look at Mac n’ chise on Twitter she’s Tweeted some promising studies regarding one dose of AZ giving a great level of protection everything she tweets is backed up by the studies.

So basically, the current vaccines are losing effectiveness

Pfizer announced today that they are developing a booster specifically tailored to the delta variant. Trials could start in August.

abcnews.go.com/Health/booster-shot-12-months-provide-best-protection-covid/story?id=78741334

[quote MissConductUS]Pfizer announced today that they are developing a booster specifically tailored to the delta variant. Trials could start in August.

abcnews.go.com/Health/booster-shot-12-months-provide-best-protection-covid/story?id=78741334[/quote]
There you go Sparklingbrook, that's some evidence for you right there.

Best,

Lucy

There you go Sparklingbrook, that's some evidence for you right there

Snippet from the Telegraph:

Laboratory analysis revealed that the mutation that originated in India is four times more able to overcome protective antibodies from a previous infection compared to the UK’s alpha variant.

The study also found that a single dose of either the Pfizer or AstraZeneca vaccines provided just 10 per cent protection against the delta variant.

The variant was already thought to be up to 60 per cent more infectious than the version which swept the UK last winter.

The findings, published in the journal Nature, help explain why the virus is spreading so quickly, particularly among younger adults, fewer of whom are double-vaccinated.

www.telegraph.co.uk/news/2021/07/08/covid-survivors-likely-reinfected-thanks-delta-variant/

I cba to dig out a link at the moment, but I recall reading that the current vaccines do offer very good protection against disease serious enough to require hospital care, even with delta. You are vastly safer vaccinated.

@Rainbowsandstorms

Have a look at Mac n’ chise on Twitter she’s Tweeted some promising studies regarding one dose of AZ giving a great level of protection everything she tweets is backed up by the studies.

MacNCheese is Twitter's equivalent of the "Good News Thread" - cherry-picking out the few encouraging figures and ignoring the wider picture.

I can't get behind the paywall, protection against what? Infection, severe illness or death?

Yes, according to this study you need a second dose for effectiveness against Delta or Beta variant.

@FourTeaFallOut

I can't get behind the paywall, protection against what? Infection, severe illness or death?

Infection. You can download the full PDF here: www.nature.com/articles/s41586-021-03777-9?utm_medium=affiliate&utm_source=commission_junction&utm_campaign=3_nsn6445_deeplink_PID100045542&utm_content=deeplink.

Perfect, thanks.

So at 16w after X2 doses AZ protection higher than Pfizer?

If Pfizer has been given with a 3 week gap, then maybe very slightly higher, and certainly immunity does seem to wane a bit from Pfizer. However in the UK we've had a longer gap for Pfizer too, which may have made it more effective and may also mean it doesn't wane as quickly. Also worth remembering this study is about infection, not severe illness or death; it's likely to still be a very tiny number who get very sick after two vaccines.

As so often, there is more to this than the thread title suggests.

The study was looking at the effect of antibodies from recovered/vaccinated individuals on the various virus strains. It used the individuals' serum. But the immune system does not just work on antibodies alone - there is a whole arsenal of weapons involved, including the T and B cells that make the news. So we learn more about the effects of vaccination by looking at real world data on infection rates, hospitalisation rates and death rates (and the relationship between them) in previously infected and in vaccinated individuals against the unvaccinated.

Using serum antibodies alone (which was all that was studied) neutralisation of the Delta variant was indeed low after recovering from Covid or a single AZ or Pfizer vaccination. But 4 weeks after the 2nd dose "81-100% (Pfizer) and 95-100% (AZ) neutralized any of the 4 strains".

On the subject of JCVI issuing interim advice on COVID-19 booster vaccination, the efficacy of the vaccines over time and on variants is being carefully and continuously monitored. The linked article clearly states "The JCVI’s interim advice is that, should a booster programme be required, and lays out the order of administration of the programme. Ie, the JCVI is preparing for the need, should it arise. It does not say that boosters are definitely known to be needed at the moment, so it does not say that protection is waning. But being prepared is better than just hanging about hoping for the best and then scrambling to put a programme in place if the need arises, I would say.

I wish there was an edit feature - I left the closing quotation marks off after 'programme be required'. And I should say the bold is all mine.

This is why allowing the virus to run rampant in the UK and hence increasing risk of more variants is troubling.

OP I had a horrible reaction to the first vaccine and none to the second.

In the news today 97% of USA citizens that died of covid were unvaccinated.

So in this study the AZ is performing better than the Pfizer?

@Pinchoftums,

May I ask you what side effects you had, and whether you still had them when you went for your second dose?